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UBD - ubiquitin D Gene

Also Known as FAT10; UBD-3; GABBR1

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 10537

About UBD

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:29,555,515-29,559,732 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 104 orthologues and 10 paralogues. Biased expression in lymph node (RPKM 113.8), appendix (RPKM 64.9) and 10 other tissues.

Summary

This gene encodes a protein which contains two ubiquitin-like domains and appears to have similar function to ubiquitin. Through covalent attachment, the encoded protein targets Other proteins for 26S Proteasome degradation. This protein has been implicated to function in many cellular processes, including caspase-dependent Apoptosis, formation of aggresomes, mitotic regulation, and dendritic cell maturation. Upregulation of this gene may promote inflammation in chronic kidney disease and has been observed in many Cancer types. [provided by RefSeq, Aug 2017]

UBD Products (1)

mRNA	Protein	Name
NM_006398.4	NP_006389.2	ubiquitin D

UBD Protein Structure

ubiquitin

0
100
165 a.a.

Protein Preferred Names	Protein Names
ubiquitin D	diubiquitin

UBD Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	UBD	O15205	PDE9A	Homo sapiens	O76083-2	Y2H Prey Pooling	32296183
Intra	UBD	O15205	PDE9A	Homo sapiens	O76083-2	Validated Y2H	32296183
Intra	UBD	O15205	PDE9A	Homo sapiens	O76083-2	Y2H Array	32296183
Intra	UBD	O15205	NUB1	Homo sapiens	Q9Y5A7	Anti Tag CoIP	33961781
Intra	UBD	O15205	UBE2Z	Homo sapiens	Q9H832	Anti Tag CoIP	24528925
Intra	UBD	O15205	UBE2Z	Homo sapiens	Q9H832	Anti Bait CoIP	24528925
Intra	UBD	O15205	MAPK8IP2	Homo sapiens	Q13387	Validated Y2H	25814554
Intra	UBD	O15205	SNCA	Homo sapiens	P37840	Validated Y2H	32814053
Intra	UBD	O15205	SNCA	Homo sapiens	P37840	Y2H Array	32814053
Intra	UBD	O15205	SNCA	Homo sapiens	P37840	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

UBD 抗体

製品番号	製品名	アプリケーション	反応性
HY-P80364	Ubiquitin D Antibody (YA021)	WB, ICC/IF, IHC-P	Human, Mouse, Rat

関連疾患

Diseases	Alias
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-139979	USP5-IN-1	Inhibitor	99.73%	Unkown
HY-155697	SGC-UBD253	Antagonist	99.3%	Unkown
HY-RS15335	UBD Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-157428	USP3 ZnF-UBD ligand-1		99.61%	Unkown
HY-172193	UBD1031	Antagonist	/	Unkown
HY-180994	HDAC6-IN-72	Inhibitor	/	Unkown
HY-W027296	UBTR008295a	Ligand	/	Unkown
HY-RS17264	Ubd Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23718	Ubd Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Macaca mulatta	UBD	VGNC	VGNC:104439
Rattus norvegicus	UBD	RGD	RGD:69418
Mus musculus	UBD	MGD	MGI:1344410
Others	UBD	NCBI