Gab1 - growth factor receptor bound protein 2-associated protein 1 Gene

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 14388

Summary

Involved in positive regulation of cell migration by vascular endothelial growth factor signaling pathway. Acts upstream of or within several processes, including cell surface receptor signaling pathway; labyrinthine layer development; and positive regulation of MAP kinase activity. Located in cytoplasm. Is expressed in several structures, including brain; genitourinary system; heart; liver; and lung. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 26. Orthologous to human GAB1 (GRB2 associated binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Gab1 Products (2)

mRNA Protein Name
NM_001301298.1 NP_001288227.1 GRB2-associated-binding protein 1 isoform 1
NM_021356.2 NP_067331.2 GRB2-associated-binding protein 1 isoform 2
Protein Preferred Names Protein Names

GRB2-associated-binding protein 1

  • GRB2-associated binder 1

Gab1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
Gab1 Q9QYY0 Grb2 Mus musculus Q60631
Y2H
10871282
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
製品番号 製品名 製品効果
純度 Rare Diseases
HY-13404 Capmatinib 99.71% Yes
HY-13404C Capmatinib dihydrochloride hydrate 99.67% Yes
HY-13404A Capmatinib dihydrochloride 99.82% Yes
HY-13404B Capmatinib hydrochloride 99.48% Unkown

Pre-clinical Phase

Bioactive Molecules (2)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS05197 GAB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10503 PIGU Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Gab1 NCBI NCBI:2549