MAN2B2 - mannosidase alpha class 2B member 2 Gene

Also Known as EpMAN

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 23324

About MAN2B2

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:6,575,189-6,623,362 (from NCBI)

This gene has 5 transcripts (splice variants), 215 orthologues and 4 paralogues. Ubiquitous expression in thyroid (RPKM 17.8), ovary (RPKM 16.8) and 25 other tissues.

Summary

Predicted to enable alpha-mannosidase activity. Predicted to be involved in mannose metabolic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

MAN2B2 Products (2)

mRNA Protein Name
NM_001292038.2 NP_001278967.1 epididymis-specific alpha-mannosidase isoform 2 precursor
NM_015274.3 NP_056089.1 epididymis-specific alpha-mannosidase isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAN2B2 Protein Structure

Glyco_hydro_38

Glyco_hydro_38: Glycosyl hydrolases family 38 N-terminal domain (29 - 351)

Alpha-mann_mid

Alpha-mann_mid: Alpha mannosidase middle domain (357 - 439)

Glyco_hydro_38C

Glyco_hydro_38C: Glycosyl hydrolases family 38 C-terminal domain (478 - 1002)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1009 a.a.
Protein Preferred Names Protein Names

epididymis-specific alpha-mannosidase

  • alpha-1,6-mannosidase

MAN2B2 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
MAN2B2 Q9Y2E5 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra
MAN2B2 Q9Y2E5 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
Intra
MAN2B2 Q9Y2E5 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
MAN2B2 Q9Y2E5 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
MAN2B2 Q9Y2E5 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
MAN2B2 Q9Y2E5 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
MAN2B2 Q9Y2E5 LIME1 Homo sapiens Q9H400
Y2H Prey Pooling
32296183
Intra
MAN2B2 Q9Y2E5 LIME1 Homo sapiens Q9H400
Y2H Array
32296183
Intra
MAN2B2 Q9Y2E5 FKBP7 Homo sapiens Q9Y680
Validated Y2H
32296183
Intra
MAN2B2 Q9Y2E5 FKBP7 Homo sapiens Q9Y680
Y2H Prey Pooling
32296183
Intra
MAN2B2 Q9Y2E5 FKBP7 Homo sapiens Q9Y680
Y2H Array
32296183
Intra
MAN2B2 Q9Y2E5 KCNK5 Homo sapiens O95279
Y2H Prey Pooling
32296183
Intra
MAN2B2 Q9Y2E5 KCNK5 Homo sapiens O95279
Y2H Array
32296183
Intra
MAN2B2 Q9Y2E5 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
MAN2B2 Q9Y2E5 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
MAN2B2 Q9Y2E5 APPBP2 Homo sapiens Q92624
Y2H Array
32296183
Intra
MAN2B2 Q9Y2E5 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
32296183
Intra
MAN2B2 Q9Y2E5 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Prey Pooling
32296183
Intra
MAN2B2 Q9Y2E5 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Mannosidosis, Beta A, Lysosomal

  • Beta-Mannosidosis

  • Lysosomal Beta-Mannosidase Deficiency

  • Beta-Mannosidase Deficiency

  • Beta-D-Mannosidosis

  • Mannosidosis, Beta

  • MANSB

  • Lysosomal Beta A Mannosidosis
Mannosidosis, Alpha B, Lysosomal

  • Alpha-Mannosidosis

  • Lysosomal Alpha-D-Mannosidase Deficiency

  • Deficiency Of Alpha-Mannosidase

  • Alpha-Mannosidase B Deficiency

  • Mannosidosis

  • MANSA

  • Mannosidosis, Alpha-, Types I And Ii

  • Alpha-D-Mannosidosis

  • Alpha-Mannosidase Deficiency

  • Α-Mannosidosis

  • Alpha Mannosidase B Deficiency

  • Mannosidosis, Alpha B Lysosomal

  • Lysosomal Alpha B Mannosidosis

  • Alpha-Mannosidosis, Infantile Form

  • Lysosomal Alpha-D-Mannosidase Deficiency, Infantile Form

  • Alpha-Mannosidosis, Adult Form

  • Lysosomal Alpha-D-Mannosidase Deficiency, Adult Form

  • Alpha-Mannosidosis Types I And Ii

  • Mannosidase Deficiency Diseases
Glycogen Storage Disease Iv

  • Gsd Iv

  • Glycogen Branching Enzyme Deficiency

  • Andersen Disease

  • Amylopectinosis

  • Glycogen Storage Disease Type Iv

  • GSD4

  • Brancher Deficiency

  • Glycogen Storage Disease, Type Iv

  • Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Congenital Neuromuscular Form

  • Gbe1 Deficiency

  • Glycogenosis Iv

  • Cirrhosis, Familial, With Deposition Of Abnormal Glycogen

  • Glycogen Storage Disease Type 4

  • Glycogenosis 4

  • Potassium-Sensitive Periodic Paralysis, Ventricular Ectopy, And Dysmorphic Features

  • Andersen'S Disease

  • Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Childhood Neuromuscular Form

  • Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Fatal Perinatal Neuromuscular Form

  • Brancher Deficiency Glycogenosis

  • Branching-Transferase Deficiency Glycogenosis

  • Deficiency Of 1,4-Alpha-Glucan Branching Enzyme

  • Andersen-Tawil Syndrome

  • Gsd 4

  • Andersen Cardiodysrhythmic Periodic Paralysis

  • Lqt7

  • Long Qt Syndrome 7

  • Periodic Paralysis, Potassium-Sensitive Cardiodysrhythmic Type

  • Andersen Glycogenosis

  • Branching Enzyme Deficiency

  • Glycogenosis, Type Iv

  • Gsd Type Iv

  • Type Iv Glycogenosis

  • Gbe Deficiency, Childhood Neuromuscular Form

  • Gsd Due To Glycogen Branching Enzyme Deficiency, Childhood Neuromuscular Form

  • Gsd Type 4, Childhood Neuromuscular Form

  • Gsdiv, Childhood Neuromuscular Form

  • Glycogen Storage Disease Type 4, Childhood Neuromuscular Form

  • Glycogen Storage Disease Type Iv, Childhood Neuromuscular Form

  • Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Childhood Neuromuscular Form

  • Glycogenosis Type 4, Childhood Neuromuscular Form

  • Glycogenosis Type Iv, Childhood Neuromuscular Form

  • Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Adult Neuromuscular Form

  • Gbe Deficiency, Adult Neuromuscular Form

  • Gsd Due To Glycogen Branching Enzyme Deficiency, Adult Neuromuscular Form

  • Gsd Type 4, Adult Neuromuscular Form

  • Gsdiv, Adult Neuromuscular Form

  • Glycogen Storage Disease Type 4, Adult Neuromuscular Form

  • Glycogen Storage Disease Type Iv, Adult Neuromuscular Form

  • Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Adult Neuromuscular Form

  • Glycogenosis Type 4, Adult Neuromuscular Form

  • Glycogenosis Type Iv, Adult Neuromuscular Form

  • Gbe Deficiency, Congenital Neuromuscular Form

  • Gsd Due To Glycogen Branching Enzyme Deficiency, Congenital Neuromuscular Form

  • Gsd Type 4, Congenital Neuromuscular Form

  • Gsdiv, Congenital Neuromuscular Form

  • Glycogen Storage Disease Type 4, Congenital Neuromuscular Form

  • Glycogen Storage Disease Type Iv, Congenital Neuromuscular Form

  • Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Congenital Neuromuscular Form

  • Glycogenosis Type 4, Congenital Neuromuscular Form

  • Glycogenosis Type Iv, Congenital Neuromuscular Form

  • Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Childhood Combined Hepatic And Myopathic Form

  • Gbe Deficiency, Childhood Combined Hepatic And Myopathic Form

  • Gsd Due To Glycogen Branching Enzyme Deficiency, Childhood Combined Hepatic And Myopathic Form

  • Gsd Type 4, Childhood Combined Hepatic And Myopathic Form

  • Gsdiv, Childhood Combined Hepatic And Myopathic Form

  • Glycogen Storage Disease Type 4, Childhood Combined Hepatic And Myopathic Form

  • Glycogen Storage Disease Type Iv, Childhood Combined Hepatic And Myopathic Form

  • Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Childhood Combined Hepatic And Myopathic Form

  • Glycogenosis Type 4, Childhood Combined Hepatic And Myopathic Form

  • Glycogenosis Type Iv, Childhood Combined Hepatic And Myopathic Form

  • Gbe Deficiency, Fatal Perinatal Neuromuscular Form

  • Gsd Due To Glycogen Branching Enzyme Deficiency, Fatal Perinatal Neuromuscular Form

  • Gsd Type 4, Fatal Perinatal Neuromuscular Form

  • Gsdiv, Fatal Perinatal Neuromuscular Form

  • Glycogen Storage Disease Type 4, Fatal Perinatal Neuromuscular Form

  • Glycogen Storage Disease Type Iv, Fatal Perinatal Neuromuscular Form

  • Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Fatal Perinatal Neuromuscular Form

  • Glycogenosis Type 4, Fatal Perinatal Neuromuscular Form

  • Glycogenosis Type Iv, Fatal Perinatal Neuromuscular Form

  • Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Non Progressive Hepatic Form

  • Gbe Deficiency, Non Progressive Hepatic Form

  • Gsd Due To Glycogen Branching Enzyme Deficiency, Non Progressive Hepatic Form

  • Gsd Type 4, Non Progressive Hepatic Form

  • Gsdiv, Non Progressive Hepatic Form

  • Glycogen Storage Disease Type 4, Non Progressive Hepatic Form

  • Glycogen Storage Disease Type Iv, Non Progressive Hepatic Form

  • Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Non Progressive Hepatic Form

  • Glycogenosis Type 4, Non Progressive Hepatic Form

  • Glycogenosis Type Iv, Non Progressive Hepatic Form

  • Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Progressive Hepatic Form

  • Gbe Deficiency, Progressive Hepatic Form

  • Gsd Due To Glycogen Branching Enzyme Deficiency, Progressive Hepatic Form

  • Gsd Type 4, Progressive Hepatic Form

  • Gsdiv, Progressive Hepatic Form

  • Glycogen Storage Disease Type 4, Progressive Hepatic Form

  • Glycogen Storage Disease Type Iv, Progressive Hepatic Form

  • Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Progressive Hepatic Form

  • Glycogenosis Type 4, Progressive Hepatic Form

  • Glycogenosis Type Iv, Progressive Hepatic Form

  • Glycogen Storage Disease 4

  • Gsd-Iv

  • Storage Disease, Glycogen, Type Iv
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS08011 MAN2B2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus MAN2B2 MGD MGI:1195262
Macaca mulatta MAN2B2 VGNC VGNC:81451
Rattus norvegicus MAN2B2 RGD RGD:1308840
Others MAN2B2 NCBI