SLF1 - SMC5-SMC6 complex localization factor 1 Gene

Also Known as BRCTx; BRCTD1; ANKRD32

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 84250

About SLF1

Cytogenetic location: 5q15 Genomic coordinates (GRCh38): 5:94,618,231-94,697,621 (from NCBI)

This gene has 8 transcripts (splice variants), 189 orthologues and 1 paralogue. Broad expression in testis (RPKM 3.1), bone marrow (RPKM 1.1) and 23 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of double-strand break repair; and protein localization to site of double-strand break. Located in nucleoplasm and site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022]

SLF1 Products (1)

mRNA Protein Name
NM_032290.4 NP_115666.2 SMC5-SMC6 complex localization factor protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
25931565 GOA
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
25931565 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
25931565 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in DNA damage response IDA
IDA: Inferred from direct assay
25931565 GOA
involved in positive regulation of double-strand break repair IDA
IDA: Inferred from direct assay
25931565 GOA
involved in positive regulation of maintenance of mitotic sister chromatid cohesion IMP
IMP: Inferred from mutant phenotype
25931565 GOA
involved in positive regulation of protein-containing complex assembly IMP
IMP: Inferred from mutant phenotype
25931565 GOA
involved in protein localization to site of double-strand break IDA
IDA: Inferred from direct assay
25931565 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in site of double-strand break IDA
IDA: Inferred from direct assay
25931565 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLF1 Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (792 - 869)

Ank

Ank: Ankyrin repeat (874 - 902)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1058 a.a.
Protein Preferred Names Protein Names

SMC5-SMC6 complex localization factor protein 1

  • BRCT domain containing 1

SLF1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
SLF1 Q9BQI6 SLF2 Homo sapiens Q8IX21
Anti Tag CoIP
33961781
Intra
SLF1 Q9BQI6 SLF2 Homo sapiens Q8IX21
Anti Tag CoIP
36373674
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Form Agnosia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS13361 SLF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus SLF1 MGD MGI:2145448
Macaca mulatta SLF1 VGNC VGNC:84493
Bos taurus SLF1 VGNC VGNC:52883
Canis familiaris SLF1 VGNC VGNC:46502
Rattus norvegicus SLF1 RGD RGD:1304857
Felis catus SLF1 VGNC VGNC:65451
Others SLF1 NCBI