ZW10 - zw10 kinetochore protein Gene

Also Known as HZW10; KNTC1AP

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 9183

About ZW10

Cytogenetic location: 11q23.2 Genomic coordinates (GRCh38): 11:113,733,187-113,773,692 (from NCBI)

This gene has 3 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in testis (RPKM 9.8), skin (RPKM 6.7) and 25 other tissues.

Summary

This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting Mitosis. [provided by RefSeq, Aug 2011]

ZW10 Products (1)

mRNA Protein Name
NM_004724.4 NP_004715.1 centromere/kinetochore protein zw10 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
11146660 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in Golgi organization IGI
IGI: Inferred from genetic interaction
20163571 GOA
involved in Golgi organization IMP
IMP: Inferred from mutant phenotype
20163571 GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
15029241 GOA
involved in establishment of mitotic spindle orientation IMP
IMP: Inferred from mutant phenotype
19468067 GOA
involved in mitotic metaphase chromosome alignment IMP
IMP: Inferred from mutant phenotype
19468067 GOA
involved in mitotic sister chromatid segregation IDA
IDA: Inferred from direct assay
11146660 GOA
involved in mitotic spindle assembly checkpoint signaling IDA
IDA: Inferred from direct assay
11146660 GOA
involved in mitotic spindle assembly checkpoint signaling IMP
IMP: Inferred from mutant phenotype
15824131 GOA
involved in protein localization to kinetochore IMP
IMP: Inferred from mutant phenotype
19468067 GOA
involved in protein-containing complex assembly IDA
IDA: Inferred from direct assay
11146660 GOA
involved in regulation of exit from mitosis IDA
IDA: Inferred from direct assay
11146660 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
part of Dsl1/NZR complex IDA
IDA: Inferred from direct assay
20462495 GOA
part of Dsl1/NZR complex IPI
IPI: Inferred from physical interaction
20462495 GOA
part of RZZ complex IDA
IDA: Inferred from direct assay
20462495 GOA
part of RZZ complex IPI
IPI: Inferred from physical interaction
25849506 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
15029241 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
11682612 GOA
located in kinetochore microtubule IDA
IDA: Inferred from direct assay
11146660 GOA
located in lipid droplet IDA
IDA: Inferred from direct assay
30970241 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15485811 GOA
located in spindle pole IDA
IDA: Inferred from direct assay
11146660 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZW10 Protein Structure

Zw10

Zw10: Centromere/kinetochore Zw10 (9 - 621)

  • 0
  • 200
  • 400
  • 600
  • 779 a.a.
Protein Preferred Names Protein Names

centromere/kinetochore protein zw10 homolog

  • ZW10 homolog, centromere/kinetochore protein

ZW10 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
ZW10 O43264 ZWINT Homo sapiens O95229
IF
15824131
Intra
ZW10 O43264 ZWINT Homo sapiens O95229
IF
16732327
Intra
ZW10 O43264 ZWINT Homo sapiens O95229
Pull Down
16732327
Intra
ZW10 O43264 RINT1 Homo sapiens Q6NUQ1
Anti Bait CoIP
20462495
Intra
ZW10 O43264 RINT1 Homo sapiens Q6NUQ1
Anti Tag CoIP
20462495
Intra
ZW10 O43264 RINT1 Homo sapiens Q6NUQ1
Anti Bait CoIP
24056303
Intra
ZW10 O43264 RINT1 Homo sapiens Q6NUQ1
TAP
15824131
Cross: Cross-species interaction Intra: Intraspecies interaction

ZW10 抗体

製品番号 製品名 アプリケーション 反応性
HY-P810269 ZW10 Antibody (YA9613) WB, IP, FC human

関連疾患

Diseases Alias
Pelger-Huet Anomaly

  • PHA

  • Pelger-Huët Anomaly

  • Ovoid Neutrophil Nuclei, Developmental Delay, Epilepsy And Skeletal Abnormalities

  • Pelger Huet Anomaly

  • Pelger-Huet Nuclear Anomaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS16208 ZW10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21464 Zw10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27982 Zw10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Canis familiaris ZW10 VGNC VGNC:48864
Rattus norvegicus ZW10 RGD RGD:1309197
Felis catus ZW10 VGNC VGNC:81067
Bos taurus ZW10 VGNC VGNC:37390
Macaca mulatta ZW10 VGNC VGNC:78915
Mus musculus ZW10 MGD MGI:1349478
Others ZW10 NCBI