iMAC2
iMAC2 is a potent MAC inhibitor with an IC50 of 28 nM and an LD50 of 15000 nM. iMAC2 shows anti-apoptotic effect. iMAC2 blocks cytochrome c release.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 335166-36-4
- 分子式: C19H20Br2FN3
- 分子量:469.19
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
IC50: 28 nM (MAC)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
0.68 μM
Compound: 13
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In vitro inhibition of Bax regulated release of cytochrome C was determined using liposome channel assay
In vitro inhibition of Bax regulated release of cytochrome C was determined using liposome channel assay
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[PMID: 14521400] |
体外実験
iMAC2 (5 μM; pre-treatment for 1 hour and then treatment for 12 hours) reduces apoptosis in FL5.12 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:FL5.12 cells
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Concentration:5 μM
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Incubation Time:Pretreatment 1 h and then treatment with Staurosporine (HY-15141) for 12 hours
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Result:Reduced apoptosis by more than 50%.
化学情報
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CAS 番号 335166-36-4
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分子量 469.19
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分子式 C19H20Br2FN3
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SMILES
FC(CN1CCNCC1)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
iMAC2 関連分類
HY-103272 関連分類
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