Isograndifoliol
Isograndifoliol is a selective inhibitor of butyrylcholinesterase (BChE) with an IC50 value of 0.9 μM. And Isograndifoliol moderately inhibits acetylcholinesterase (AChE) with an IC50 value of 342.9 μM. Isograndifoliol also has vasorelaxant effect and anti-tumor effect. Isograndifoliol can be used for research against dementia caused by neurodegenerative diseases.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1445475-53-5
- 分子式: C19H26O3
- 分子量:302.41
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
AChE 342.9 μM (IC50) |
BChE 0.9 μM (IC50) |
体外実験
Isograndifoliol exhibits dose-dependent vasorelaxant effects on rat aortic rings, preconstricted by KCl or norepinephrine, with EC50 values of 36.36-74.51 μg/mL[2].
Isograndifoliol exhibits potent activity against HL-60 cells with an IC50 value of 0.33 μM[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
化学情報
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CAS 番号 1445475-53-5
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分子量 302.41
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分子式 C19H26O3
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SMILES
CC1=CC2=C(C=C(C1=O)O)[C@](CCCC3(C)C)(CO)[C@H]3CC2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Ślusarczyk S, et al. Norditerpenoids with Selective Anti-Cholinesterase Activity from the Roots of Perovskia atriplicifolia Benth. Int J Mol Sci. 2020 Jun 23;21(12):4475. [Content Brief]
[2]. Kang J, et al. Isolation and bioactivity of diterpenoids from the roots of Salvia grandifolia. Phytochemistry. 2015 Aug;116:337-348. [Content Brief]
[3]. Tsukada H, et al. Two New Diterpenoids from Salvia przewarskii. Nat Prod Commun. 2016 Feb;11(2):159-61. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Isograndifoliol 関連分類
HY-N10781 関連分類
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