KS124
KS124 (compound 3) is a potent ALDH inhibitor. KS124 shows inhibition for ALDH1A1, ALDH1A3, ALDH3A1. KS124 shows antiproliferative activity. KS124 induces apoptosis and ROS production.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C21H12Br2N2O7
- 分子量:564.14
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
KS124 (compound 3) (3 µM; 24, 48 h) induces apoptosis in a time-dependent manner in HCT-116 cells[1].
KS124 (3 µM; 48 h) increases ROS production in HCT-116 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT-116, SKOV-3, MIA PaCa-2, HEK-293, FHC cells
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Concentration:0-50 µM
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Incubation Time:48 h
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Result:Inhibited cell viability with IC50s of 2.2, 3.8, 2.1, 8.7, 7.1 µM for HCT-116, SKOV-3, MIA PaCa-2, HEK-293, FHC cells, respectively.
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Cell Line:HCT-116 cells
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Concentration:3 µM
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Incubation Time:24 h, 48 h
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Result:Induced apoptosis with the late apoptotic cell populations of 12.30%, 15.45% at 24, 48 h, respectively.
化学情報
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分子量 564.14
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分子式 C21H12Br2N2O7
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SMILES
O=C(C1=CC=C([N+]([O-])=O)O1)OCC2=CC=C(CN3C(C(C4=C3C(Br)=CC(Br)=C4)=O)=O)C=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
KS124 関連分類
HY-159111 関連分類
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