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製品番号: HY-182678

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L-731988

L-731988 is an inhibitor targeting HIV-1 integrase. L-731988 inhibits HIV-1 replication by blocking integrase function. L-731988 exhibits ED₅₀ values ranging from 0.5 μM to 3.14 μM against various HIV-1 isolates. L-731988 can be used for the research of human immunodeficiency virus type 1 (HIV-1) infection.

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CAS 番号: 251922-77-7
分子式: C₁₅H₁₂FNO₄
分子量:289.26

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

L-731988 構造式

CAS 番号: 251922-77-7

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	CC₅₀	10 μM Compound: L-731988	Cytotoxicity against human HCT116 cells expressing p53 after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells expressing p53 after 72 hrs by MTT assay	[PMID: 19026554]

体外実験

L-731988 (0.5-5.0 μM) suppresses RT activity of HIV-1 primary isolates in PBLs in a dose-dependent manner^[1].
L-731988 inhibits replication of diverse primary HIV-1 isolates in PBLs, with ED₅₀ values ranging from 0.544 to 3.14 μM; most isolates show less-than-twofold differences in susceptibility relative to HIV_LAI, while HIV_92RW009 exhibits a sixfold reduction in susceptibility^[1].
L-731988 inhibits HIV-1 replication in MT-2 cells with ED₅₀ values ranging from 0.505 to 1.6 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Infectious Diseases

化学情報

CAS 番号 251922-77-7
分子量 289.26
分子式 C₁₅H₁₂FNO₄
SMILES

O=C(C(CC(C1=CC=CN1CC2=CC=C(C=C2)F)=O)=O)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Reinke R, et al. Inhibition of human immunodeficiency virus type 1 isolates by the integrase inhibitor L-731,988, a diketo Acid. Antimicrob Agents Chemother. 2002 Oct;46(10):3301-3.

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100 mg

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