L-m-Tyrosine
Based on 1 Customer Validation
L-m-Tyrosine is an unnatural amino acid. L-m-Tyrosine reduces dopamine, norepinephrine and serotonin in rats. L-m-Tyrosine has potential in the research of Parkinsons disease, Alzheimers disease, and arthritis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.94%
- CAS 番号: 587-33-7
- 分子式: C9H11NO3
- 分子量:181.19
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
体外実験
L-m-tyrosine is converted to dopamine by partially purified rat liver phenylalanine hydroxylase and bovine adrenal medullary tyrosine hydroxylase[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 587-33-7
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性状 Solid
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分子量 181.19
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分子式 C9H11NO3
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Color Off-white to light yellow
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SMILES
N[C@H](C(O)=O)CC1=CC(O)=CC=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : < 1 mg/mL (insoluble or slightly soluble)
プロトコル
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Collagen-Induced Arthritis
Collagen-induced arthritis (CIA) is an autoimmune murine model of rheumatoid arthritis in which immunization with type II collagen (CII) emulsified in an adjuvant induces a T cell- and autoantibody-driven inflammatory arthritis characterized by synovial hyperplasia, immune cell infiltration, and joint destruction. The model typically relies on genetically susceptible mouse strains (e. g. , DBA/1) and reproduces key features of human rheumatoid arthritis, including anti-collagen immune responses and progressive joint inflammation. Disease onset generally occurs within ~3-4 weeks after immunization, depending on antigen/adjuvant combinations and protocol variation. The immunopathology is driven by adaptive immune activation against CII, leading to systemic and local joint inflammation mediated by pro-inflammatory cytokines and effector immune cells, making CIA a standard preclinical platform for evaluating immunomodulatory and anti-arthritic interventions.
純度とドキュメンテーション
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データシート (276 KB)
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- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
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- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. M H Fukami ,et al. Phenylalanine as Substrate for Tyrosine Hydroxylase in Bovine Adrenal Chromaffin Cells. Biochem J. 1990 Jun 1;268(2):525-8. [Content Brief]
[2]. Ishimitsu S, et al. Studies on the formation of 3,4-dihydroxyphenylalanine, m-tyrosine and o-tyrosine from L-phenylalanine by rat liver and adrenal. Chem Pharm Bull (Tokyo). 1988 Jan;36(1):279-85. [Content Brief]
[3]. Smyth RG, et al. Studies on the depletion of brain amines by m-tyrosine. Eur J Pharmacol. 1977 Apr 7;42(3):267-73. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
L-m-Tyrosine 関連分類
HY-W016443 関連分類
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