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製品番号: HY-18330

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MI 63

MI 63 is an activator for p53, by targeting the MDM2 (K_i is 3 nM). MI 63 inhibits the proliferation of embryonic and alveolar rhabdomyosarcoma (ERMS and ARMS) cells (IC₅₀ is 0.58 μM in RH36 cells), and induces apoptosis in ERMS and ARMS.

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CAS 番号: 908027-21-4
分子式: C₂₉H₃₅Cl₂FN₄O₃
分子量:577.52

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

MI 63 構造式

CAS 番号: 908027-21-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	GI₅₀	1.19 μM Compound: 2a, MI-63	Growth inhibition of human A2780 cells expressing MDM2 by SRB assay Growth inhibition of human A2780 cells expressing MDM2 by SRB assay	[PMID: 21875801]
HCT-116	GI₅₀	1.3 μM Compound: 2a, MI-63	Growth inhibition of human HCT116 cells expressing MDM2 by SRB assay Growth inhibition of human HCT116 cells expressing MDM2 by SRB assay	[PMID: 21875801]
HCT-116	GI₅₀	11.8 μM Compound: 2a, MI-63	Growth inhibition of p53 deficient human HCT116 cells expressing MDM2 by SRB assay Growth inhibition of p53 deficient human HCT116 cells expressing MDM2 by SRB assay	[PMID: 21875801]
HCT-116	IC₅₀	0.7 μM Compound: 1, MI-63	Growth inhibition of human HCT116 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay Growth inhibition of human HCT116 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay	[PMID: 19928922]
HCT-116	IC₅₀	14.4 μM Compound: 1, MI-63	Growth inhibition of human HCT116 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay Growth inhibition of human HCT116 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay	[PMID: 19928922]
LNCaP	IC₅₀	280 nM Compound: 8, MI-63	Antiproliferative activity against human LnCAP cell line with wild type p53 Antiproliferative activity against human LnCAP cell line with wild type p53	[PMID: 16759082]
PC-3	IC₅₀	18 μM Compound: 8, MI-63	Antiproliferative activity against human PC3 cell line with deleted p53 Antiproliferative activity against human PC3 cell line with deleted p53	[PMID: 16759082]
SAOS-2	IC₅₀	14.1 μM Compound: 1, MI-63	Growth inhibition of human Saos2 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay Growth inhibition of human Saos2 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay	[PMID: 19928922]
SJSA-1	GI₅₀	0.55 μM Compound: 2a, MI-63	Growth inhibition of human SJSA1 cells expressing MDM2 by SRB assay Growth inhibition of human SJSA1 cells expressing MDM2 by SRB assay	[PMID: 21875801]
SJSA-1	IC₅₀	0.5 μM Compound: 1, MI-63	Growth inhibition of human SJSA1 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay Growth inhibition of human SJSA1 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay	[PMID: 19928922]

化学情報

CAS 番号 908027-21-4
分子量 577.52
分子式 C₂₉H₃₅Cl₂FN₄O₃
SMILES

O=C([C@H](N[C@@H]1CC(C)(C)C)[C@H](C2=CC=CC(Cl)=C2F)[C@]31C(NC4=C3C=CC(Cl)=C4)=O)NCCN5CCOCC5
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Canner JA, et al., MI-63: a novel small-molecule inhibitor targets MDM2 and induces apoptosis in embryonal and alveolar rhabdomyosarcoma cells with wild-type p53. Br J Cancer. 2009 Sep 1;101(5):774-81. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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