Midafotel
Based on 1 Customer Validation
Midafotel (SDZ-EAA 494) is a potent and comprtitive NMDA antagonist with an ED50 value of 39 nM. Midafotel causes intense stereotyped behaviors. Midafotel shows neuroprotective effects.
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- 純度: 99.00%
- CAS 番号: 117414-74-1
- 分子式: C8H15N2O5P
- 分子量:250.19
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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NMDA Receptor 39 nM () |
Midafotel (1.5, 4.5, 15 mg/kg; i.v.; initiated 15 min prior to MCA occlusion (followed by constant infusion at 1, 3 or 10 mg/kg/h)) produces dose-dependent reductions in the volumes of infarction; the dose of 4.5 mg/kg being the most effective in focal cerebral ischemia in the rat[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult female Wistar rats[2]
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Dosage:15 mg/kg
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Administration:I.p.
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Result:Induced the typical PCP-like behavioral syndrome with ataxia, hyperlocomotion and stereotyped behaviors, i.e., head weaving, stereotyped sniffing, face washing and grooming, significantly increased extracellular levels of HVA and 5-HIAA in the striatum.
化学情報
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CAS 番号 117414-74-1
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性状 Solid
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分子量 250.19
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分子式 C8H15N2O5P
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Color White to off-white
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SMILES
OC([C@H]1CN(CCN1)C/C=C/P(O)(O)=O)=O
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別名
SDZ-EAA 494
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
H2O : 25 mg/mL (99.92 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Lowe DA, et al. D-CPP-ene (SDZ EAA 494), a potent and competitive N-methyl-D-aspartate (NMDA) antagonist: effect on spontaneous activity and NMDA-induced depolarizations in the rat neocortical slice preparation, compared with other CPP derivatives and MK-801. Neurosci Lett. 1990 Jun 8;113(3):315-21. [Content Brief]
[2]. Potschka H, et al. Effects of the NMDA receptor antagonist D-CPPene on extracellular levels of dopamine and dopamine and serotonin metabolites in striatum of kindled and non-kindled rats. Eur J Pharmacol. 1999 Jun 18;374(2):175-87. [Content Brief]
[3]. Park CK, McCulloch J, Kang JK, Choi CR. Efficacy of D-CPPene, a competitive N-methyl-D-aspartate antagonist in focal cerebral ischemia in the rat. Neurosci Lett. 1992 Nov 23;147(1):41-4. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.9970 mL | 19.9848 mL | 39.9696 mL | 99.9241 mL |
| 5 mM | 0.7994 mL | 3.9970 mL | 7.9939 mL | 19.9848 mL | |
| 10 mM | 0.3997 mL | 1.9985 mL | 3.9970 mL | 9.9924 mL | |
| 15 mM | 0.2665 mL | 1.3323 mL | 2.6646 mL | 6.6616 mL | |
| 20 mM | 0.1998 mL | 0.9992 mL | 1.9985 mL | 4.9962 mL | |
| 25 mM | 0.1599 mL | 0.7994 mL | 1.5988 mL | 3.9970 mL | |
| 30 mM | 0.1332 mL | 0.6662 mL | 1.3323 mL | 3.3308 mL | |
| 40 mM | 0.0999 mL | 0.4996 mL | 0.9992 mL | 2.4981 mL | |
| 50 mM | 0.0799 mL | 0.3997 mL | 0.7994 mL | 1.9985 mL | |
| 60 mM | 0.0666 mL | 0.3331 mL | 0.6662 mL | 1.6654 mL | |
| 80 mM | 0.0500 mL | 0.2498 mL | 0.4996 mL | 1.2491 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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