MK-0493
Based on 1 Customer Validation
MK-0493 is an orally active melanocortin-4 receptor (MC4R) agonist. MK-0493 reduces food intake, suppresses weight gain, elevates blood pressure at high doses, and exhibits preclinical erectile regulatory activity. MK-0493 can be used in research related to obesity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.19%
- CAS 番号: 455956-93-1
- 分子式: C30H38ClF2N3O2
- 分子量:546.09
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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MC4R |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 455956-93-1
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性状 Solid
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分子量 546.09
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分子式 C30H38ClF2N3O2
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Color White to light yellow
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SMILES
CC(N[C@@H](C)C1=CC(Cl)=CC=C1C2CCN(CC2)C([C@@H]3CN(C[C@H]3C4=CC=C(C=C4F)F)C(C)(C)C)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (183.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Krishna R, etal. Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: energy intake predicts lack of weight loss efficacy. Clin Pharmacol Ther. 2009 Dec;86(6):659-66. [Content Brief]
[2]. Krishna R, et al. Lack of erectogenic activity of a novel selective melanocortin-4 receptor agonist in a clinical experimental model. J Clin Pharmacol. 2008 Oct;48(10):1237-41. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8312 mL | 9.1560 mL | 18.3120 mL | 45.7800 mL |
| 5 mM | 0.3662 mL | 1.8312 mL | 3.6624 mL | 9.1560 mL | |
| 10 mM | 0.1831 mL | 0.9156 mL | 1.8312 mL | 4.5780 mL | |
| 15 mM | 0.1221 mL | 0.6104 mL | 1.2208 mL | 3.0520 mL | |
| 20 mM | 0.0916 mL | 0.4578 mL | 0.9156 mL | 2.2890 mL | |
| 25 mM | 0.0732 mL | 0.3662 mL | 0.7325 mL | 1.8312 mL | |
| 30 mM | 0.0610 mL | 0.3052 mL | 0.6104 mL | 1.5260 mL | |
| 40 mM | 0.0458 mL | 0.2289 mL | 0.4578 mL | 1.1445 mL | |
| 50 mM | 0.0366 mL | 0.1831 mL | 0.3662 mL | 0.9156 mL | |
| 60 mM | 0.0305 mL | 0.1526 mL | 0.3052 mL | 0.7630 mL | |
| 80 mM | 0.0229 mL | 0.1144 mL | 0.2289 mL | 0.5722 mL | |
| 100 mM | 0.0183 mL | 0.0916 mL | 0.1831 mL | 0.4578 mL |
MK-0493 関連分類
HY-118930 関連分類
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