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United States

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製品番号: HY-136348

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ML338

ML338 is a selective small molecule inhibitor probe of non-replicating Mycobacterium tuberculosis bacilli and is against the non-replicating M. tuberculosis with IC₉₀ and IC₉₉ values of 1 μM and 4 μM, respectively by CFU. ML338 is a invaluable tool for identifying both essential functions and vulnerabilities of the M. tuberculosis bacilli in the nutrient deprivation states. ML338 can be used for the study of M. tuberculosis chemotherapy.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1630160-25-6
分子式: C₁₇H₁₂ClN₅OS
分子量:369.83

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

ML338 構造式

CAS 番号: 1630160-25-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

IC90: 1 μM (non-replicating Mycobacterium tuberculosis bacilli)
IC99: 4 μM (non-replicating Mycobacterium tuberculosis bacilli)

体外実験

ML338 (0-50 μM) has potency and selectivity against non-replicating M. tuberculosis with an IC₉₀ of 1 μM. Additionally, ML338 have an IC₉₉ against non-replicating M. tuberculosis (4 μM) which is excellent relative to current TB drugs^[1].
ML338 (0-50 μM; 48 hours) shows no toxicity to J774 macrophage cells up to 50 μM, the highest concentration^[1].
ML338 is against the non-replicating M. tuberculosis with IC₉₀ and IC₉₉ velues of 1 μM and 4 μM, respectively by CFU. Additionally, it against the replicating M. tuberculosis with IC₉₀ and IC₉₉ velues of 62 μM and 62 μM, respectively by CFU^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1630160-25-6
分子量 369.83
分子式 C₁₇H₁₂ClN₅OS
SMILES

ClC1=CC=C(C2=NN=C(SCC3=CN(C4=CC=CC=C4)N=N3)O2)C=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (278 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Partha P. Nag,et al. Elucidation of the Physiology of Non-Replicating, Drug Tolerant Mycobacterium tuberculosis With the Aid of the Small Molecule Probe ML338. Review [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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