MMG-0358
MMG-0358 is a potent IDO1 inhibitor. MMG-0358 shows IC50 values of 2 nM in a cellular assay on mIDO1, 80 nM in a cellular assay on hIDO1, 330 nM in an enzymatic assay on hIDO1 at pH 6.5, and 71 nM in an enzymatic assay on hIDO1 at pH 7.4.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1378976-02-3
- 分子式: C8H6ClN3O
- 分子量:195.61
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
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IDO1 330 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
0.082 μM
Compound: MMG-0358
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Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrs
Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrs
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[PMID: 31525930] |
| P815 | IC50 |
>100 μM
Compound: 35, MMG-0358
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Inhibition of mouse TDO in P815 clone 12 cells by HPLC analysis
Inhibition of mouse TDO in P815 clone 12 cells by HPLC analysis
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[PMID: 22616902] |
| P815 | IC50 |
0.002 μM
Compound: 35, MMG-0358
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Inhibition of mouse IDO1 in P815 clone 6 cells by HPLC analysis
Inhibition of mouse IDO1 in P815 clone 6 cells by HPLC analysis
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[PMID: 22616902] |
化学情報
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CAS 番号 1378976-02-3
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分子量 195.61
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分子式 C8H6ClN3O
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SMILES
ClC1=CC(C2=CN=NN2)=C(O)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MMG-0358 関連分類
HY-120742 関連分類
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