country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-188256

Copy Link Print Information

NSC66098

NSC66098 is an RNA-binding agent. NSC66098 binds to expanded CAG repeat RNA containing AA mismatches and inhibits its pathogenic function. NSC66098 protects cells from proteotoxicity induced by polyglutamine aggregates. NSC66098 can be used in research on Huntington's disease and spinocerebellar ataxia.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3259-43-6
分子式: C₁₅H₁₁FN₂S
分子量:270.32

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

NSC66098 構造式

CAS 番号: 3259-43-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示 :

体外実験

NSC66098 binds (5′CAG/3′GAC) x6 RNA with nanomolar affinity in ITC and discriminates against the control 5′CAG/3′GUC duplex RNA with micromolar affinity^[1].
NSC66098 selectively blocks (5′CAG/3′GAC) RNA and inhibits PCR amplification of CAG-repeat DNA, without comparable effects on controls^[1].
NSC66098 protects Cos-7 cells from proteotoxicity induced by polyglutamine aggregates^[1].
NSC66098 (24 h) reduces Thioflavin T fluorescence of protein aggregates in HD-derived GM04281 fibroblasts in a concentration-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 3259-43-6
分子量 270.32
分子式 C₁₅H₁₁FN₂S
SMILES

FC1=CC=C2N=NC=C(C2=C1)SCC3=CC=CC=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Khan E, et al. Discovery of a potent small molecule inhibiting Huntington's disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein. Scientific reports. 2019 Nov 14;9(1):16872.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ