Nuclear localizing sequence
Nuclear localizing sequence is a peptide sequence that functions as an inducer and exhibits membrane permeability in mammalian cells. Nuclear localizing sequence enhances cellular uptake and directs conjugated ruthenium (II) complexes to the nucleus for nuclear DNA imaging.
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- CAS 番号: 503474-42-8
- 分子式: C55H103N21O12S
- 分子量:1282.60
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
The nuclear localizing sequence (Compound 12a) targets the conjugated [Ru (bpy)2 (dppz)]2+ complex to the cell nucleus, and enables selective imaging of nuclear DNA by virtue of the "light-switch" emission behavior of this complex[1].
Conjugation of the nuclear localizing sequence with a ruthenium (II) biquinoline complex bearing perchlorate counterions enables efficient cellular uptake in CHO and HeLa cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 503474-42-8
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分子量 1282.60
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分子式 C55H103N21O12S
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配列
Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-NH2
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シーケンスの短縮
VQRKRQKLMP-NH2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Lee LC, et al. Luminescent and Photofunctional Transition Metal Complexes: From Molecular Design to Diagnostic and Therapeutic Applications. J Am Chem Soc. 2022;144(32):14420-14440. [Content Brief]
[2]. Cullinane D, et al. Photostable NIR emitting ruthenium(II) conjugates; uptake and biological activity in live cells. J Inorg Biochem. 2020;207:111032. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Nuclear localizing sequence 関連分類
HY-P11744 関連分類
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