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製品番号: HY-164585

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P-gp modulator-6

P-gp modulator-6 is a P-glycoprotein (P-gp) modulator. P-gp modulator-6 regulates the substrate specificity of P-gp and enhances the efflux activity of Daunorubicin (HY-13062A) and Rhodamine 123 (HY-D0816). P-gp modulator-6 can be used in the research of multidrug-resistant cancers. P-gp modulator-6 can be used in the research of multidrug-resistant pancreatic cancer and multidrug-resistant colon cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 352652-36-9
分子式: C₁₆H₁₃ClN₂O₂
分子量:300.74

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

P-gp modulator-6 構造式

CAS 番号: 352652-36-9

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]^[2]

P-gp

体外実験

P-gp modulator-6 (10 μM; 2 h) more potently stimulates P-gp-mediated efflux of daunorubicin than Rho-123 in mouse fibroblast Con A cells when used at 10 μM for 2 h^[1].
P-gp modulator-6 (Dilution series; 5 days) exhibits similar antiproliferative activity against parental EPG85-257P and daunorubicin-resistant EPG85-257RDB gastric carcinoma cells, with reduced activity against mitoxantrone-resistant EPG85-257RNOV gastric carcinoma cells (IC₅₀ = 53.8 µM, RR = 2.51)^[2].
P-gp modulator-6 (Dilution series; 5 days) exhibits antiproliferative activity against parental EPP85-181P pancreatic carcinoma cells, with reduced activity against daunorubicin-resistant EPP85-181RDB cells and increased activity against mitoxantrone-resistant EPP85-181RNOV cells (IC₅₀ = 33.6 µM, RR = 0.61)^[2].
P-gp modulator-6 (Dilution series; 5 days) exhibits antiproliferative activity against parental HT-29P colon carcinoma cells, with a collateral sensitivity effect against daunorubicin-resistant HT-29RDB cells (IC₅₀ = 30.7 µM, RR = 0.50) and mitoxantrone-resistant HT-29RNOV cells (IC₅₀ = 19.3 µM, RR = 0.31)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:

Human gastric carcinoma cell lines (parental EPG85-257P, daunorubicin-resistant EPG85-257RDB, mitoxantrone-resistant EPG85-257RNOV)
Concentration:

Dilution series
Incubation Time:

5 days
Result:

Exhibited antiproliferative activity against parental EPG85-257P cells with an IC₅₀ of 21.4 µM.
Showed similar antiproliferative activity against daunorubicin-resistant EPG85-257RDB cells with an IC₅₀ of 19.9 µM and a relative resistance ratio (RR) of 0.93.
Had reduced antiproliferative activity against mitoxantrone-resistant EPG85-257RNOV cells with an IC₅₀ of 53.8 µM and an RR of 2.51.

Cell Proliferation Assay^[2]

Cell Line:

Human pancreatic carcinoma cell lines (parental EPP85-181P, daunorubicin-resistant EPP85-181RDB, mitoxantrone-resistant EPP85-181RNOV)
Concentration:

Dilution series
Incubation Time:

5 days
Result:

Exhibited antiproliferative activity against parental EPP85-181P cells with an IC₅₀ of 55.1 µM.
Had reduced antiproliferative activity against daunorubicin-resistant EPP85-181RDB cells with an IC₅₀ of 85.6 µM and an RR of 1.55.
Showed increased antiproliferative activity against mitoxantrone-resistant EPP85-181RNOV cells with an IC₅₀ of 33.6 µM and an RR of 0.61.

Cell Proliferation Assay^[2]

Cell Line:

human colon carcinoma cell lines (parental HT-29P, daunorubicin-resistant HT-29RDB, mitoxantrone-resistant HT-29RNOV)
Concentration:

Dilution series
Incubation Time:

5 days
Result:

Exhibited antiproliferative activity against parental HT-29P cells with an IC₅₀ of 61.5 µM.
Showed increased antiproliferative activity against daunorubicin-resistant HT-29RDB cells with an IC₅₀ of 30.7 µM and an RR of 0.50.
Showed increased antiproliferative activity against mitoxantrone-resistant HT-29RNOV cells with an IC₅₀ of 19.3 µM and an RR of 0.31.

化学情報

CAS 番号 352652-36-9
分子量 300.74
分子式 C₁₆H₁₃ClN₂O₂
SMILES

ClC1=CC=C(CC2=NOC(C3=C(OC)C=CC=C3)=N2)C=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Kondratov RV, et al. Small molecules that dramatically alter multidrug resistance phenotype by modulating the substrate specificity of P-glycoprotein. Proceedings of the National Academy of Sciences of the United States of America. 2001 Nov 20;98(24):14078-83. [Content Brief]

[2]. Ramalhete C, et al. Triterpenoids from Momordica balsamina with a Collateral Sensitivity Effect for Tackling Multidrug Resistance in Cancer Cells. Planta medica. 2018 Dec;84(18):1372-1379. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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P-gp modulator-6

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

P-gp modulator-6 関連分類

HY-164585 関連分類