PAD4-IN-3
PAD4-IN-3 (compound 4B) is a PAD4 inhibitor with antitumor activity in vitro and in vivo. PAD4-IN-3 was covalently linked to RGD sequence peptide-modified chitosan (K-CRGDV), resulting in an enhanced oxidative stress-responsive nanoagent. K-CRGDV-PAD4-IN-3 can actively target tumors, inhibit PAD4 activity, block the formation of neutrophil extracellular traps (NETs), and improve the tumor immune microenvironment in response to the tumor microenvironment.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2642327-44-2
- 分子式: C21H26BClN4O4
- 分子量:444.72
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
PAD4[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 4T1 | IC50 |
>100 μM
Compound: 5a
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Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
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[PMID: 37421890] |
化学情報
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CAS 番号 2642327-44-2
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分子量 444.72
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分子式 C21H26BClN4O4
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SMILES
O=C(NCC1=CC=CC=C1)[C@H](CCCNC(CCl)=N)NC(C2=CC(B(O)O)=CC=C2)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PAD4-IN-3 関連分類
HY-157157 関連分類
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