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United States

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製品番号: HY-163277

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PIPE-3297

PIPE-3297 (compound 25) is a selective kappa opioid receptor (KOR) agonist, which activates the G-protein signaling with EC₅₀ of 1.1 nM and exhibits low β-arrestin-2 recruitment activity (10%). PIPE-3297 induces myelination and reveals an anti-inflammatory activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₃H₃₀N₂O
分子量:350.50

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

PIPE-3297 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

IC₅₀ & Target

κ Opioid Receptor/KOR

1.1 nM (EC₅₀)

Opioid Receptor アイソフォーム固有の製品をすべて表示 :

体外実験

PIPE-3297 induces myelination and causes oligodendrocyte progenitor cells (OPCs) differentiation into oligodendrocytes (OLs)^[1].
PIPE-3297 exhibits cardiotoxity with 72% hERG inhibition (3 μM) and unstability in liver microsomes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

OPC
Concentration:

0.5-1 μM
Incubation Time:

72 h
Result:

Increased levels of MBPs

体内実験

PIPE-3297 (30 mg/kg, s.c., single dosage) leads a KOR occupancy of 90% in CNS and reaches a brain concentration of 12.5 μM. in C57BL/6 mice, reveals no evidence of KOR-mediated hypolocomotion^[1].
PIPE-3297 (30 mg/kg, s.c., single dosage) induces KOR-dependent OPC differentiation into mature OLs in C57BL/6 mice^[1].
PIPE-3297 (3 and 30 mg/kg, s.c., daily for 23 days) ameliorates the autoimmune encephalomyelitis (EAE) induced by myelin oligodendrocyte glycoprotein (MOG) in C57BL/6 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

MOG induced EAE in C57BL/6 mice^[1]
Dosage:

3 and 30 mg/kg
Administration:

s.c., daily for 23 days
Result:

Ameliorated the EAE.

Animal Model:

C57BL/6 mice^[1]
Dosage:

3 and 30 mg/kg
Administration:

s.c., single dose
Result:

Increased levels of KOR and mature OLs, maintained the locomotion ability.

化学情報

分子量 350.50
分子式 C₂₃H₃₀N₂O
SMILES

OC1=CC=CC(CCN(C2CN(C2)CC3=CC=CC=C3)CC4CCC4)=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Schrader TO,et al., Identification and In Vivo Evaluation of Myelination Agent PIPE-3297, a Selective Kappa Opioid Receptor Agonist Devoid of β-Arrestin-2 Recruitment Efficacy. ACS Chem Neurosci. 2024 Feb 7;15(3):685-698. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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