Prednimustine
Based on 1 Customer Validation
Prednimustine (Leo 1031;NSC 134087) is the ester formed from Prednisolone (HY-17463) and Chlorambucil (HY-13593). Prednimustine can be used for leukemias and lymphomas research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 95.58%
- CAS 番号: 29069-24-7
- 分子式: C35H45Cl2NO6
- 分子量:646.64
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体内実験
Prednimustine (40 mg/kg; s.c.; single dose) produces low plasma concentrations (less than 5 microM) of the alkylating metabolites chlorambucil and phenyl acetic mustard, which were maintained for 48 h in rats bearing the sensitive strain of the Walker 256 carcinosarcoma grown as an ascites[1].
Prednimustine (40 mg/kg;s.c.; single dose; measured at 72 h) shows antitumor effect in rats model with the alkylating agent-resistant strain of the Yoshida sarcoma[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Wistar rats non-tumour-bearing (150-200g)[1]
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Dosage:120 mg/kg
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Administration:Subcutaneous injection; single dose; observed at day 21
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Result:Remained 100% survival of rats, while 0% survival for Chlorambucil treatment group.
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Animal Model:Female Wistar rats bearing the alkylating agent-resistant strain of the Yoshida sarcoma (150-200g)[1]
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Dosage:40 mg/kg
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Administration:Subcutaneous injection; single dose
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Result:Killed 57% of the resistant tumour cells.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 29069-24-7
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性状 Solid
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分子量 646.64
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分子式 C35H45Cl2NO6
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Color White to light yellow
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SMILES
C[C@@]12[C@](C(COC(CCCC3=CC=C(N(CCCl)CCCl)C=C3)=O)=O)(O)CC[C@@]1([H])[C@]4([H])CCC5=CC(C=C[C@]5(C)[C@@]4([H])[C@@H](O)C2)=O
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別名
Leo 1031; NSC 134087
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (154.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.5465 mL | 7.7323 mL | 15.4646 mL | 38.6614 mL |
| 5 mM | 0.3093 mL | 1.5465 mL | 3.0929 mL | 7.7323 mL | |
| 10 mM | 0.1546 mL | 0.7732 mL | 1.5465 mL | 3.8661 mL | |
| 15 mM | 0.1031 mL | 0.5155 mL | 1.0310 mL | 2.5774 mL | |
| 20 mM | 0.0773 mL | 0.3866 mL | 0.7732 mL | 1.9331 mL | |
| 25 mM | 0.0619 mL | 0.3093 mL | 0.6186 mL | 1.5465 mL | |
| 30 mM | 0.0515 mL | 0.2577 mL | 0.5155 mL | 1.2887 mL | |
| 40 mM | 0.0387 mL | 0.1933 mL | 0.3866 mL | 0.9665 mL | |
| 50 mM | 0.0309 mL | 0.1546 mL | 0.3093 mL | 0.7732 mL | |
| 60 mM | 0.0258 mL | 0.1289 mL | 0.2577 mL | 0.6444 mL | |
| 80 mM | 0.0193 mL | 0.0967 mL | 0.1933 mL | 0.4833 mL | |
| 100 mM | 0.0155 mL | 0.0773 mL | 0.1546 mL | 0.3866 mL |
Prednimustine 関連分類
HY-13732 関連分類
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