ERK3/MAPK6
null ERK3 (MAPK6) is an atypical MAP kinase that departs from the family in several respects. Its activation segment contains a single SEG phospho-acceptor motif instead of the canonical TEY, it is not activated by MEK1/2 or by stress stimuli, and it is constitutively phosphorylated in cells. A long C-terminal extension mediates binding to MAPK-activated protein kinase 5, the principal known substrate, which ERK3 activates and stabilizes. Protein levels are controlled by ubiquitin-dependent degradation. ERK3 supports endothelial cell migration and angiogenesis, and knockout mice show growth retardation with poor neonatal survival. Recombinant ERK3 is used for atypical-MAPK biochemistry and inhibitor screening.
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ERK3/MAPK6 組換えタンパク質 (2)
- 生物種:
- 由来:
- 生物種:
- 由来:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 分子式: Human
- 分子量: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
