country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-158119A

Copy Link Print Information

PSMA-trillium

(別名: Felivotide mopaxetan)

PSMA-trillium (Felivotide mopaxetan) is a PSMA-targeted molecule that contains a highly specific PSMA-binding motif, an albumin-binding domain optimized for tumor uptake and retention, and a Macropa chelator conjugated to the α-emitter ²²⁵Ac. PSMA-trillium binds to albumin to prolong plasma retention time and binds to PSMA via its specific motif. ²²⁵Ac-PSMA-Trillium exhibits dose-dependent inhibition of LNCaP tumor growth in mice. PSMA-trillium can be used in research related to prostate cancer and metastatic castration-resistant prostate cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3036415-37-6
分子式: C₁₀₆H₁₅₆IN₁₇O₃₄S
分子量:2371.44

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

PSMA-trillium 構造式

CAS 番号: 3036415-37-6

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

²²⁵Ac-PSMA-trillium maintains favorable stability for up to 48 h^[1].
²²⁵Ac-PSMA-trillium (0.114 kBq/mL) potently induces cytotoxicity in C4-2, a subclone of the prostate cancer cell line LNCaP^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

²²⁵Ac-PSMA-Trillium (100-400 kBq/kg; intravenous injection; single dose) exhibits dose-dependent inhibition of LNCaP tumor growth and reduces tumor weight in male SCID mice, with higher tumor uptake and faster renal clearance compared to the control agent ²²⁵Ac-PSMA-SMOL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SCID (male)^[2]
Dosage:

100 kBq/kg; 400 kBq/kg
Administration:

i.v.; single injection
Result:

Showed higher tumor uptake compared to other 225Ac-PSMA-SMOLs, with homogeneous tumor accumulation 60 hours after injection and fast clearance from the kidneys.
Inhibited LNCaP tumor growth and decreased tumor weights in a dose-dependent manner.

化学情報

CAS 番号 3036415-37-6
分子量 2371.44
分子式 C₁₀₆H₁₅₆IN₁₇O₃₄S
SMILES

O=C([C@@H](NC(N[C@H](C(O)=O)CCCCNC(NC1=CC(C2=CN(N=N2)CCOCCOCCOCCC(N[C@H](C(NCCOCCOCCOCCOCCOCCOCCOCCOCCC(N[C@H](C(O)=O)CCCCNC(CCCC3=CC=C(I)C=C3)=O)=O)=O)CCCCNC(NC4=CC=C(C=C4)CCOC5=CC(C(O)=O)=NC(CN6CCOCCOCCN(CC7=CC=CC(C(O)=O)=N7)CCOCCOCC6)=C5)=S)=O)=CC=C1)=O)=O)CCC(O)=O)O
別名

Felivotide mopaxetan
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (274 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Zitzmann-Kolbe S, et al. Preclinical evaluation of an actinium-225 labeled PSMA-targeting small molecule (225Ac-PSMA-Trillium (BAY 3563254)) for the treatment of metastatic castration resistant prostate cancer (mCRPC)[J]. Cancer Research, 2024, 84(6_Supplement): 6033-6033.

[2]. Hagemann U B, et al. Comparative evaluation of 225Ac-PSMA-Trillium with other 225Ac-PSMA-SMOL assets in a preclinical prostate cancer xenograft model[J]. Cancer Research, 2026, 86(7_Supplement): 7202-7202.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ