SPDZi1
SPDZi1 is a potent and selective syntenin inhibitor that binds to PDZ1 and PDZ2 domains of syntenin. SPDZi1 binds to the syntenin PDZ tandem (STNPDZ) with a Kd of 3.6 μM. SPDZi1 suppresses glioblastoma and reduces the activation of NF-κB, a downstream effector of syntenin.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C22H19N3O5
- 分子量:405.40
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
SPDZi1 (Z3322068027; 20 μM; 24 h) inhibits human glioblastoma multiforme (GBM) cell proliferation while concurrently reducing the activation of NF-κB[1].
In glioblastoma organoids (GBOs), SPDZi1 effectively suppresses the growth of small GBOs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:U87-MG
-
Concentration:20 μM
-
Incubation Time:24 h
-
Result:Demonstrated a profound inhibitory effect on human GBM cell proliferation.
化学情報
-
分子量 405.40
-
分子式 C22H19N3O5
-
SMILES
O=C(N[C@@H](CC(N1)=NC=CC1=O)C(O)=O)OCC(C2=C3C=CC=C2)C4=C3C=CC=C4
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SPDZi1 関連分類
HY-162510 関連分類
Powered by Bioz