Stromatoxin 1

Stromatoxin 1 (100 µM) increases insulin secretion from MIN6 cells and pancreatic β cells/islets in the presence of glucose^[2].
Stromatoxin 1 has a weak effect on the action potential of human pancreatic β cells, with the peak voltage remaining at -21 mV both in the absence and presence of blockers^[4].
Stromatoxin 1 (1 μM; 1 h) does not significantly affect glucose-induced insulin secretion in intact human pancreatic islets^[4].

Stromatoxin 1 (100 nM) inhibits peak and sustained voltage-dependent outward K⁺ currents in MIN6 cells^[2].
Stromatoxin 1 (100 nM) reduces AHPD50 by 18%, shortens the refractory period, and increases the probability of AP conduction during repetitive stimulation in naïve rat L4/L5 DRG neurons^[3].
Stromatoxin 1 selectively inhibits slowly inactivating Kv2.1/2.2-mediated K⁺ currents in human pancreatic β cells, reducing the sustained current by 45% and the peak current by 15%^[4].
Stromatoxin 1 (100 nM; 60 min) depolarizes the resting membrane potential of rat whisker follicle Merkel cells from -48 mV to -40 mV without affecting action potential properties, membrane capacitance, or input resistance^[5].
Stromatoxin 1 (100 nM) inhibits voltage step-induced K_V currents in freshly isolated human DSM cells at positive voltages (+10 to +30 mV)^[6].
Stromatoxin 1 (100 nM; 20 min) increases intracellular Ca²⁺ levels in freshly isolated human DSM cells^[6].
Stromatoxin 1 (100 nM; 10 min) increases the amplitude and force of spontaneous phasic contractions in isolated human DSM strips without significantly altering contraction frequency, duration, or muscle tone^[6].
Stromatoxin 1 (100 nM; 30 min) enhances EFS-induced contractions in human DSM isolated strips across the 3.5-30 Hz stimulation range^[6].
Stromatoxin 1 (100 nM) inhibits a component of whole-cell Kv currents in guinea pig DSM cells and alters activation kinetics, and the ScTx1-sensitive current exhibits biophysical properties consistent with Kv2.1-containing channels^[7].
Stromatoxin 1 (100 nM; 10 min) does not change the resting membrane potential of guinea pig DSM cells^[7].
Stromatoxin 1 (100 nM) increases spontaneous and EFS-induced contractions of guinea pig DSM strips, has only a slight effect on the amplitude of carbachol-induced phasic contractions, and has no effect on KCl-induced contractions^[7].