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製品番号: HY-N18411

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Tanacetin

Tanacetin is a sesquiterpenoid compound discovered in the whole herb of Crossostephium chinense (L.) Makino. Sesquiterpene lactones, the class to which Tanacetin belongs (e.g., constituents of plants in the Tanacetum genus), inhibit the inflammatory mediators prostaglandins and leukotrienes. Tanacetin crosses intestinal cell monolayers primarily via transcellular passive diffusion, and no significant first-pass metabolism occurs during its intestinal absorption. Tanacetin is used in research related to diabetes, migraine, and rheumatoid arthritis.

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CAS 番号: 1401-54-3
分子式: C₁₅H₂₀O₄
分子量:264.32

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Tanacetin 構造式

CAS 番号: 1401-54-3

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Tanacetin (100 mg; 1 h at 65°C) treated with 0.9 mg NaOCH₃ in 100 mL MeOH converts it to crossostephin with a 20.1% yield, as confirmed by spectroscopic and optical rotation analysis^[1].
Tanacetin (10-200 μM; 30-180 min) is well absorbed across Caco-2 cell monolayers primarily via passive diffusion through the transcellular pathway, with an AP→BL P_app of 1.77×10^-5 cm/s and no significant first-pass metabolism^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1401-54-3
分子量 264.32
分子式 C₁₅H₂₀O₄
SMILES

O[C@@]12[C@]3([H])[C@@](C(C(O3)=O)=C)([H])CC[C@]1([C@@H](CCC2=C)O)C
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Wu Q, et al. Novel sesquiterpene and coumarin constituents from the whole herbs of Crossostephium chinense. J Asian Nat Prod Res. 2009;11(1):85-90.

[2]. Wu Q, et al. Intestinal permeability of sesquiterpenes in the caco-2 cell monolayer model. Planta medica. 2010 Mar;76(4):319-24.

[3]. Zou L, et al. [Effects of chemical constituents of Crossostephium chinense on insulin secretion in rat islets in vitro]. Zhongguo Zhong Yao Za Zhi. 2009 Jun;34(11):1401-5.

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100 mg

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