Tebuconazole-d9
Tebuconazole-d9 is the deuterium labeled Tebuconazole. Tebuconazole is an agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1246818-83-6
- 分子式: C16H13D9ClN3O
- 分子量:316.87
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-N3463
Isopimaric acidConifer Defense Compound -
HY-W250116
Co(III) protoporphyrin IX chlorideHO-1 Inducer -
HY-N10546A
Ganglioside GM1 (bovine) ammoniumGlycosphingolipid -
HY-152055S
Glufosinate-d3 hydrochlorideStable Isotope -
HY-B0916S
Propoxur-d3Stable Isotope -
HY-B0847S
Propiconazole-d7Stable Isotope -
HY-17386S
Rosiglitazone-d3Stable Isotope -
HY-17004S1
Olmesartan-d6Stable Isotope -
HY-A0166S
Cilastatin-15N,d3Stable Isotope -
HY-100806S
Kynurenic acid-d5Stable Isotope -
HY-111614
Melengestrol acetateContraceptive Agent -
HY-126816
Atrazine mercapturateEndogenous Metabolite
生物活性
製品説明
体外実験
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HepG2 cells
-
Concentration:20,40,80 μM
-
Incubation Time:1–12 hours
-
Result:Increased the nuclear translocation of peroxisome proliferator-activated receptors and the expression of cluster of differentiation 36, fatty acid transport protein (FATP) 2, FATP5, and carnitine palmitoyltransferase 1.
-
Cell Line:Bovine mammary gland epithelial cells (MAC-T cells)
-
Concentration:100,150,200,250,500,750 μM
-
Incubation Time:24 hours
-
Result:Decreased cells viability and proliferation and activates apoptotic cell death via the upregulation of pro-apoptotic proteins, such as cleaved caspases 3 and 8 and BAX.
Induced loss of mitochondrial membrane potential in MAC-T cells.
Induced mitochondria-mediated apoptotic MAC-T cell death by activating ER stress.
Induced endoplasmic reticulum (ER) stress via the upregulation of Bip/GRP78; PDI; ATF4; CHOP; and ERO1-Lα.
アプリケーション
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
-
CAS 番号 1246818-83-6
-
非標識Cas 107534-96-3
-
分子量 316.87
-
分子式 C16H13D9ClN3O
-
SMILES
OC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])(CCC1=CC=C(Cl)C=C1)CN2C=NC=N2
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Warrilow AG, et al. Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens. Antimicrob Agents Chemother. 2013 Mar;57(3):1352-60. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Tebuconazole-d9 関連分類
HY-B0852S 関連分類
Powered by Bioz