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製品番号: HY-125265

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JTP-117968

JTP-117968, a novel selective glucocorticoid receptor modulator (a non-steroidal SGRM, IC₅₀ of 6.8 nM), exhibits improved transrepression/transactivation dissociation.

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CAS 番号: 2250132-99-9
分子式: C₃₁H₃₁F₃N₂O₂
分子量:520.59

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

JTP-117968 構造式

CAS 番号: 2250132-99-9

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

JTP-117968, a novel selective glucocorticoid receptor modulator (a non-steroidal SGRM, IC₅₀ of 6.8 nM), exhibits improved transrepression/transactivation dissociation^[1].

体外実験

JTP-117968 has partial TR activity, but exhibits extremely low TA activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Endocrine Diseases

化学情報

CAS 番号 2250132-99-9
分子量 520.59
分子式 C₃₁H₃₁F₃N₂O₂
SMILES

O=C(C(C=C1C2)=CC=C1[C@]3(CC4=CC=CC=C4)CC[C@@](C(F)(F)F)(O)C[C@@]3([H])C52CC5)NC6=CC=CN=C6C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Takafumi Kurimoto, et al. JTP-117968, a novel selective glucocorticoid receptor modulator, exhibits improved transrepression/transactivation dissociation. Eur J Pharmacol. 2017 May 15;803:179-186. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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