Psen1 - presenilin 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29192

Summary

Enables endopeptidase activity. Involved in several processes, including negative regulation of neuron apoptotic process; neural retina development; and proteolysis. Located in several cellular components, including cytoplasmic vesicle; lysosomal membrane; and sarcolemma. Part of protein-containing complex. Is integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease (multiple); Pick's disease; dilated cardiomyopathy 1U; frontotemporal dementia; and hidradenitis suppurativa. Orthologous to human PSEN1 (presenilin 1). [provided by Alliance of Genome Resources, Apr 2022]

Psen1 Products (1)

mRNA Protein Name
NM_019163.4 NP_062036.2 presenilin-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables endopeptidase activity IDA
IDA: Inferred from direct assay
15456764 RGD
enables peptidase activity IDA
IDA: Inferred from direct assay
15456764 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12297508 RGD
Biological Process GO Annotation Evidence References Source
involved in cerebellum development IEP
IEP: Inferred from expression pattern
16298244 RGD
involved in membrane protein ectodomain proteolysis IMP
IMP: Inferred from mutant phenotype
17433308 RGD
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
11895366 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
11895366 RGD
involved in neural retina development IEP
IEP: Inferred from expression pattern
12401445 RGD
involved in protein processing IDA
IDA: Inferred from direct assay
15456764 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
11570818 RGD
located in early endosome IDA
IDA: Inferred from direct assay
20126630 RGD
located in lysosomal membrane IDA
IDA: Inferred from direct assay
12736250 RGD
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
12099705 RGD
located in neuromuscular junction IDA
IDA: Inferred from direct assay
16595164 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
20126630 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
15456764 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
16595164 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
20126630 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
20126630 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

presenilin-1

  • PS-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-14174 MRK-560 Inhibitor 99.92% Unkown
HY-W015515 L-Citronellol Inhibitor 99.92% Unkown
HY-156012 PSEN1-IN-2 Inhibitor / Unkown
HY-P1378A β-Amyloid (1-43)(human) TFA 95.42% Unkown
HY-156011 PSEN1-IN-1 Inhibitor / Unkown
HY-178128 PSEN1-IN-3 / Unkown
HY-180997 Aβ aggregation-IN-5 Inhibitor / Unkown
HY-P1378 β-Amyloid (1-43)(human) / Unkown
HY-RS11276 PSEN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18076 Psen1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24551 Psen1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Psen1 NCBI NCBI:5663