PRKAR2A - protein kinase cAMP-dependent type II regulatory subunit alpha Gene

Also Known as PKR2; PRKAR2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5576

About PRKAR2A

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,744,591-48,847,874 (from NCBI)

This gene has 7 transcripts (splice variants), 283 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 11.3), colon (RPKM 10.8) and 25 other tissues.

Summary

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008]

PRKAR2A Products (4)

mRNA	Protein	Name
NM_001321982.2	NP_001308911.1	cAMP-dependent protein kinase type II-alpha regulatory subunit isoform a
NM_001321983.2	NP_001308912.1	cAMP-dependent protein kinase type II-alpha regulatory subunit isoform b
NM_001321989.2	NP_001308918.1	cAMP-dependent protein kinase type II-alpha regulatory subunit isoform c
NM_004157.4	NP_004148.1	cAMP-dependent protein kinase type II-alpha regulatory subunit isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cAMP-dependent protein kinase inhibitor activity	IDA IDA: Inferred from direct assay	21812984	GOA
enables cAMP-dependent protein kinase regulator activity	IDA IDA: Inferred from direct assay	21812984	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9473338	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	25097019	GOA
enables protein kinase A catalytic subunit binding	IPI IPI: Inferred from physical interaction	17911601	GOA
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	21423175	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of cAMP/PKA signal transduction	IDA IDA: Inferred from direct assay	21812984	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with axoneme	IDA IDA: Inferred from direct assay	12475942	GOA
part of cAMP-dependent protein kinase complex	IDA IDA: Inferred from direct assay	12475942	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21423175	GOA
part of nucleotide-activated protein kinase complex	IDA IDA: Inferred from direct assay	21812984	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21423175	GOA
located in plasma membrane raft	IDA IDA: Inferred from direct assay	17911601	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	25097019	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKAR2A Protein Structure

RIIa

cNMP_binding

0
100
200
300
404 a.a.

Protein Preferred Names	Protein Names
cAMP-dependent protein kinase type II-alpha regulatory subunit	cAMP-dependent protein kinase regulatory subunit RII alpha

PRKAR2A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PRKAR2A	P13861	AKAP1	Homo sapiens	Q92667	Anti Bait CoIP	24083380
Intra	PRKAR2A	P13861	AKAP3	Homo sapiens	O75969	Pull Down	11278869

Cross: Cross-species interaction Intra: Intraspecies interaction

PRKAR2A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80429	PKA R2/PKR2 Antibody (YA132)	WB, IHC-P, IP	Human
HY-P80847	Phospho-PKA R2/PKR2 (Ser99) Antibody	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat, Pig

Related Diseases

Diseases	Alias
Nivelon-Nivelon-Mabille Syndrome	Chondrodysplasia-Pseudohermaphroditism Syndrome NNMS Chondrodysplasia-Disorder Of Sex Development Syndrome Nivelon Nivelon Mabille Syndrome
Carney Complex Variant	Carney Complex Carney Syndrome Carney Complex, Type 1 Lamb Syndrome Name Syndrome Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome Carney Complex - Trismus - Pseudocamptodactyly Syndrome Carney Complex, Type 2 Car Cnc1 Carney Myxoma-Endocrine Complex Myxoma - Spotty Pigmentation - Endocrine Overactivity Myxoma, Spotty Pigmentation, And Endocrine Overactivity Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome Carney Complex-Trismus-Pseudocamptodactyly Syndrome CACOV
Fibrolamellar Carcinoma	Fibrolamellar Hepatocellular Carcinoma Fhcc Fibrolamellar Hepatocarcinoma Hepatocellular Carcinoma, Fibrolamellar Oncocytic Hepatocellular Tumor Eosinophilic Glassy Cell Hepatoma Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis Fl-Hcc Fibrolamellar Oncocytic Hepatoma Hepatocellular Carcinoma With Increased Stromal Fibrosis Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma
Primary Pigmented Nodular Adrenocortical Disease	Ppnad Primary Pigmented Nodular Adrenal Dysplasia Pigmented Nodular Adrenocortical Disease, Primary, 2 Pigmented Nodular Adrenocortical Disease, Primary, 1
Kallmann Syndrome	Hypogonadism With Anosmia Kallman'S Syndrome Anosmic Hypogonadism Anosmic Idiopathic Hypogonadotropic Hypogonadism Hypogonadotropic Hypogonadism And Anosmia Hypogonadotropic Hypogonadism-Anosmia Syndrome Olfacto-Genital Pathological Sequence Familial Hypogonadism With Anosmia Kallman Syndrome Dysplasia Olfactogenitalis Of De Morsier Kallmann'S Syndrome Congenital Hypogonadotropic Hypogonadism With Anosmia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11114	PRKAR2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22020	Prkar2a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28538	Prkar2a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PRKAR2A	VGNC	VGNC:76407
Mus musculus	PRKAR2A	MGD	MGI:108025
Rattus norvegicus	PRKAR2A	RGD	RGD:3393
Felis catus	PRKAR2A	VGNC	VGNC:69053
Canis familiaris	PRKAR2A	VGNC	VGNC:44976
Bos taurus	PRKAR2A	VGNC	VGNC:33325
Others	PRKAR2A	NCBI