NKX2-1 - NK2 homeobox 1 Gene

Also Known as BCH; BHC; NK-2; TEBP; TTF1; NKX2A; NMTC1; T/EBP; TITF1; TTF-1; NKX2.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7080

About NKX2-1

Cytogenetic location: 14q13.3 Genomic coordinates (GRCh38): 14:36,516,397-36,520,232 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues, 13 paralogues and is associated with 76 phenotypes. Biased expression in lung (RPKM 35.0) and thyroid (RPKM 29.1).

Summary

This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid Cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb 2014]

NKX2-1 Products (2)

mRNA	Protein	Name
NM_001079668.3	NP_001073136.1	homeobox protein Nkx-2.1 isoform 1
NM_003317.4	NP_003308.1	homeobox protein Nkx-2.1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IMP IMP: Inferred from mutant phenotype	7635972	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	7559607	GOA
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	19176457	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23143308	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	17220277	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	23382074	GOA
enables intronic transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23143308	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11152647	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	1735431	GOA
enables transcription cis-regulatory region binding	IMP IMP: Inferred from mutant phenotype	19176457	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in brain development	IMP IMP: Inferred from mutant phenotype	11971878	GOA
involved in epithelial tube branching involved in lung morphogenesis	IEP IEP: Inferred from expression pattern	8675988	GOA
involved in forebrain development	IEP IEP: Inferred from expression pattern	15494458	GOA
involved in globus pallidus development	IMP IMP: Inferred from mutant phenotype	11854319	GOA
involved in lung development	IEP IEP: Inferred from expression pattern	15494458	GOA
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	19293183	GOA
involved in negative regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	19293183	GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23143308	GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	19293183	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14960358	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19176457	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	16960125	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7559607	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	25060702	GOA
involved in response to hormone	IEP IEP: Inferred from expression pattern	16960125	GOA
involved in thyroid gland development	IEP IEP: Inferred from expression pattern	15494458	GOA
involved in thyroid gland development	IMP IMP: Inferred from mutant phenotype	11854319	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	7713914	GOA
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	25060702	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NKX2-1 Protein Structure

Homeobox

0
100
200
300
401 a.a.

Protein Preferred Names	Protein Names
homeobox protein Nkx-2.1	NK-2 homolog A

NKX2-1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NKX2-1	P43699	CCDC59	Homo sapiens	Q9P031	Y2H	11152647
Intra	NKX2-1	P43699	CCDC59	Homo sapiens	Q9P031	Anti Tag CoIP	11152647
Intra	NKX2-1	P43699	NCK1	Homo sapiens	P16333	Peptide Array	17474147

Cross: Cross-species interaction Intra: Intraspecies interaction

NKX2-1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82552	TTF-1 Antibody (YA2297)	WB, ICC/IF	Human, Hamster
HY-P82552A	TTF-1 Antibody (YA2297)(PBS only)	WB, ICC/IF	Human, Hamster
HY-P85945	TTF-1 Antibody (YA5637)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
HY-P86155	TTF-1 Antibody (YA5847)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86917	TTF-1 Antibody (YA6610)	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, mIHC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Chorea, Benign Hereditary	Benign Hereditary Chorea BHC Chorea, Hereditary Benign Benign Familial Chorea Bch Hereditary Progressive Chorea Without Dementia Chorea Familial Benign Hereditary Chorea Without Dementia Chorea Benign Hereditary Bche Deficiency Chorea, Hereditary, Benign Chorea, Benign Familial
Choreoathetosis And Congenital Hypothyroidism With Or Without Pulmonary Dysfunction	Brain-Lung-Thyroid Syndrome Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress CAHTP Blt Syndrome Choreoathetosis-Hypothyroidism-Neonatal Respiratory Distress Syndrome Choreoathetosis-Hypothyroidism-Neonatal Respiratory Distress Brain-Thyroid-Lung Syndrome Chreoathetosis And Congenital Hypothyroidism With Or Without Pulmonary Dysfunction
Thyroid Cancer, Nonmedullary, 1	Papillary Thyroid Carcinoma Familial Nonmedullary Thyroid Cancer, Papillary Nonmedullary Thyroid Carcinoma, Papillary Papillary Thyroid Cancer NMTC1 Papillary Carcinoma Of Thyroid Pact Thyroid Carcinoma, Papillary Non-Medullary Thyroid Carcinoma Thyroid Cancer, Non-Medullary, 1 Familial Non-Medullary Thyroid Cancer Fnmtc Nmtc Nonmedullary Thyroid Carcinoma Ptc Tpc Thyroid Papillary Carcinoma Cancer, Thyroid, Nonmedullary Cancer, Thyroid, Nonmedullary, Type 1 Thyroid Carcinoma, Nonmedullary 1 Familial Nonmedullary Thyroid Gland Carcinoma Papillary Carcinoma, Diffuse Sclerosing, Thyroid Gland
Nkx2-1-Related Disorders	Nkx2-1-Related Disorder
Large Cell Carcinoma	Carcinoma, Large Cell Carcinoma Large Cell
Papillary Adenocarcinoma	Infiltrating And Papillary Adenocarcinoma Infiltrating Papillary Adenocarcinoma Adenocarcinoma Papillary Adenocarcinoma, Papillary
Hypothyroidism	Thyroid Diseases Thyroid Disease Thyroid Deficiency Thyroid Insufficiency Dysfunction Thyroid Thyroid Dysfunction
Struma Ovarii
Pulmonary Sclerosing Hemangioma	Pneumocytoma
Carcinoid Tumors, Intestinal	Carcinoid Gastrointestinal Carcinoid Tumor Argentaffinoma Intestinal Carcinoid Tumor ICT Tumor, Carcinoid, Intestinal Malignant Carcinoid Syndrome Carcinoid Tumor Of Intestine Carcinoid Tumor Carcinoid Tumor No Icd-O Subtype
Lung Benign Neoplasm	Lung Neoplasms Tumor Of The Lung Lung Tumor
Bronchiolo-Alveolar Adenocarcinoma	Bronchioloalveolar Carcinoma Bronchioalveolar Lung Carcinoma Minimally Invasive Lung Adenocarcinoma Carcinoma Bronchioloalveolar Adenocarcinoma, Bronchiolo-Alveolar Bronchioloalveolar Adenocarcinoma
Sclerosing Hemangioma	Sclerosing Haemangioma Cutaneous Fibrous Histiocytoma
Pulmonary Blastoma	Blastoma Of Lung Pneumoblastoma
Congenital Hypothyroidism	Cretinism Neonatal Hypothyroidism Ch Cht Congenital Myxedema Myxedema, Congenital Endemic Cretinism Congenital Iodine-Deficiency Syndrome Fetal Iodine Deficiency Syndrome Congenital Iodine-Deficiency Hypothyroidism Nos
Merkel Cell Carcinoma	Trabecular Adenocarcinoma Cutaneous Neuroendocrine Carcinoma Trabecular Carcinoma Carcinoma, Merkel Cell Merkel Cell Cancer Merkle Tumors Mcc Carcinoma Merkel Cell
Blastoma	Embryoma
Thymus Cancer	Thymic Neoplasm Thymic Tumor Thymus Neoplasm Thymus Neoplasms Malignant Neoplasm Of Thymus Neoplasm Of Thymus Thymic Neoplasms Thymoma, Familial Thymic Carcinoma Thymoma, Type C Cancer Of Thymus Malignant Tumour Of Thymus Primary Malignant Neoplasm Of Thymus Thymic Glandular Cancer Thymus Gland Cancer
Neuroendocrine Carcinoma	Neuroendocrine Cancer Carcinoma Neuroendocrine Carcinoma, Neuroendocrine
Papillary Carcinoma	Carcinoma, Papillary Carcinoma Papillary
Athyreosis
Thymic Carcinoma	Malignant Thymoma Thymoma, Malignant
Athetosis
Thyroid Gland Cancer	Thyroid Gland Carcinoma Malignant Neoplasm Of Thyroid Gland Malignant Tumour Of Thyroid Gland Thyroid Neoplasm Thyroid Neoplasms Neoplasm Of Thyroid Gland Thyroid Gland Neoplasm Head And Neck Cancer, Thyroid Neoplasm Of The Thyroid Gland Cancer Of The Thyroid Primary Malignant Neoplasm Of Thyroglossal Duct Malignant Neoplasm Of Thyroglossal Duct Primary Malignant Neoplasm Of Thyroid Gland Thyroglossal Duct Cancer Toxic Goitre Malignant Tumour Cancerous Goitre
Posterior Pituitary Gland Neoplasm	Posterior Pituitary Tumor Neoplasm Of The Posterior Pituitary
Bronchial Mucus Gland Adenoma	Adenoma Of Bronchial Mucus Gland Adenoma Of The Bronchial Mucus Gland
Bronchial Benign Neoplasm	Bronchus Neoplasm Neoplasm Of Bronchus Bronchial Neoplasms Bronchial Neoplasm
Hemangioma	Hemangiomas
Alveoli Adenoma	Alveolar Adenoma Adenoma Of Alveoli Adenoma Of The Alveoli
Goiter	Goitre
Trachea Carcinoma	Pancoast Tumor Carcinoma Of The Trachea Pancoast'S Tumor Malignant Superior Sulcus Tumor Malignant Superior Sulcus Tumour Pancoast Tumour Pancoast'S Syndrome Pancoast'S Tumour Pulmonary Sulcus Tumor Pulmonary Sulcus Tumour Superior Pulmonary Sulcus Syndrome Pancoast Syndrome
Intestinal Perforation	Perforation Of Intestine
Neurohypophysis Granular Cell Tumor	Granular Cell Tumor Of The Neurohypophysis
Mucinous Bronchioloalveolar Adenocarcinoma	Bronchiolo-Alveolar Carcinoma, Mucinous
Pleomorphic Carcinoma
Thyroid Gland Anaplastic Carcinoma	Anaplastic Thyroid Carcinoma Anaplastic Thyroid Cancer Thyroid Cancer, Anaplastic Thyroid Carcinoma, Anaplastic Thyroid Carcinoma Anaplastic
Ovarian Germ Cell Teratoma	Germ Cell Teratoma Of Ovary Ovarian Teratoma
Differentiated Thyroid Carcinoma	Papillary Or Follicular Thyroid Carcinoma Well-Differentiated Thyroid Carcinoma Differentiated Thyroid Gland Carcinoma
Frontal Sinus Cancer	Malignant Neoplasm Of Frontal Sinus Malignant Tumor Of Frontal Sinus Malignant Tumor Of The Frontal Sinus Neoplasm Of Frontal Sinus
Frontal Sinus Squamous Cell Carcinoma	Epidermoid Carcinoma Of The Frontal Sinus
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Thyroglossal Duct Cyst, Familial	Familial Thyroglossal Duct Cyst Thyroglossal Duct Cyst Hereditary Thyroglossal Duct Cysts Thyroglossal Duct Cysts Thyroglossal Duct Cysts Familial Thyroglossal Cyst
Plasma Cell Neoplasm	Plasma Cell Dyscrasia Paraproteinemias Plasma Cell Tumour Plasmacytic Tumor Multiple Myeloma Plasmacytoma Plasma Cell Tumours Plasma Cells Dyscrasia
Mucinous Lung Adenocarcinoma
Papillary Thyroid Microcarcinoma
Adenosquamous Carcinoma	Adenosquamous Cell Carcinoma Mixed Adenocarcinoma And Squamous Carcinoma Carcinoma Adenosquamous Carcinoma, Adenosquamous
Larynx Sarcoma	Sarcoma Of Larynx Laryngeal Sarcoma
Benign Mesothelioma	Mesothelioma Benign Tumor Of Mesothelium Adenomatoid Tumor
Pneumothorax	Pneumothorax Nos Air Leak Nos Pleural Air Leak Nos
Respiratory Failure	Acute Respiratory Failure Chronic Respiratory Failure Respiratory Insufficiency Acute-On-Chronic Respiratory Failure Respiratory Disease Acute And Chronic Respiratory Failure Respiratory Insufficiency/Failure Chronic Respiratory Disease Pulmonary Valve Insufficiency Chronic Disease Of Respiratory System Respiration Disorders Respiratory Tract Diseases Lung Failure Nos Pulmonary Failure Arf - [Acute Respiratory Failure] Acute Respiratory Insufficiency Acute Pulmonary Insufficiency Acute Respiration Failure Chronic Respiration Failure
Teratoma	Teratomas
Follicular Adenoma	Follicular Adenoma Of The Thyroid Gland Thyroid Follicular Adenoma Adenoma Follicular Follicular Thyroid Adenoma Thyroid Gland Follicular Adenoma
Adenomatoid Tumor	Adenomatoid Tumour Benign Localised Epithelial Mesothelioma Benign Localized Epithelial Mesothelioma
Granular Cell Tumor	Abrikosov'S Tumor Neoplasm Of Granular Cell Abrikosoff'S Granulous Cell Tumor Abrikosoff'S Tumor Giant Granulocellular Abrikosov'S Tumor Malignant Variant Of Abrikosov'S Tumor Carcinoma, Granular Cell
Thymoma	Primary Thymic Epithelial Neoplasm Primary Thymic Epithelial Tumor Thymus Neoplasms
Nonmucinous Bronchioloalveolar Adenocarcinoma
Mesothelioma, Malignant	Malignant Mesothelioma Pleural Mesothelioma MESOM Mesothelioma, Somatic Advanced Malignant Mesothelioma Asbestos-Related Malignant Mesothelioma Diffuse Malignant Mesothelioma Malignant Tumor Of Mesothelium Malignant Mesothelioma, Susceptibility To Mesothelioma Diffuse Malignant Mesothelioma Malignant Pleural Mesothelioma
Third Ventricle Chordoid Glioma	Chordoid Glioma Of The Third Ventricle Chordoid Glioma Of 3rd Ventricle Chordoid Glioma Of Third Ventricle
Newborn Respiratory Distress Syndrome	Hyaline Membrane Disease Respiratory Distress Syndrome Of Newborn Neonatal Respiratory Distress Hmd - Hyaline Membrane Disease Neonatal Respiratory Distress Syndrome Pulmonary Hyaline Membrane Disease Pulmonary Hypoperfusion Syndrome Of Newborn Respiratory Distress Syndrome, Newborn Respiratory Distress Syndrome Cardiorespiratory Distress Syndrome Of Newborn Distress Respiratory Syndrome Newborn Idiopathic Respiratory Distress Syndrome Idiopathic Respiratory Distress Syndrome Of Newborn Newborn Idiopathic Respiratory Distress Syndrome Respiratory Distress Syndrome In Newborn Rds - [Respiratory Distress Syndrome] Of Newborn Newborn Cardiorespiratory Distress Syndrome
Papillary Adenoma	Glandular Papilloma Adenoma
Small Cell Cancer Of The Lung	Small Cell Lung Cancer Small Cell Lung Carcinoma Sclc Small-Cell Cancer Of Lung Lung Small Cell Carcinoma Sclc1 Sccl Cancer, Lung, Small Cell Small Cell Carcinoma Of Lung Carcinoma, Small Cell
Respiratory System Benign Neoplasm
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Large Cell Neuroendocrine Carcinoma
Hypothyroidism, Congenital, Nongoitrous, 2	Thyroid Dysgenesis CHNG2 Thyroid Hypoplasia Thyroid Hemiagenesis Thyroid Agenesis Athyreotic Hypothyroidism Rtsh Thyrotropin Resistance Hypothyroidism, Congenital, Due To Thyroid Dysgenesis Or Hypoplasia Congenital Nongoitrous Hypothyroidism 2 Thyroid, Ectopic Hypothyroidism, Congenital, Due To Thyroid Dysgenesis Hypothyroidism, Athyreotic Thyrotropin Resistance To Thyrotropin Congenital Hypothyroidism Due To Thyroid Dysgenesis Or Hypoplasia Hypothyroidism, Congenital, Non-Goitrous, 2 Congenital Hypothyroidism Due To Thyroid Dysgenesis Thyroid-Stimulating Hormone Resistance Thyroid Ectopic Ectopic Thyroid Hypothyroidism, Congenital, Nongoitrous, 3 Thyroid Hormone Resistance Syndrome Hypothyroidism, Congenital, Nongoitrous, 1
Bronchus Adenoma	Bronchial Adenoma Adenoma Of The Bronchus
Lung Large Cell Carcinoma	Large Cell Carcinoma Of Lung Large Cell Lung Carcinoma Large Cell Lung Cancer
Diaphragmatic Hernia, Congenital	Congenital Diaphragmatic Hernia Diaphragmatic Hernia Cdh Congenital Diaphragmatic Defect Hernia, Diaphragmatic Dih Hernia, Congenital Diaphragmatic Hcd Diaphragmatic Defect, Congenital Diaphragm, Unilateral Agenesis Of Hemidiaphragm, Agenesis Of Diaphragmatic Hernia 1 Agenesis Of Hemidiaphragm Unilateral Agenesis Of Diaphragm Hernia Diaphragmatic Hernia Diaphragmatic Congenital Hernia, Diaphragmatic, Type 1 Hiatus Hernia Oesophageal Hiatus Hernia Paraoesophageal Hernia Sliding Hiatus Hernia Congenital Diaphragm Hernia Congenital Diaphragm Defect With Hernia Gross Congenital Diaphragm Defect
Benign Teratoma	Dermoid Cyst Cystic Dermoid Choristoma Dermoid Choristoma Mature Cystic Teratoma Dermoid Tumour Teratoma, Benign Dermoid Cyst Of Ovary
Neonatal Respiratory Failure	Respiratory Failure Of Newborn Inadequate Pulmonary Ventilation Of Newborn Newborn Lung Insufficiency Newborn Pulmonary Function Inadequate Newborn Pulmonary Insufficiency Newborn Respiration Failure Newborn Respiratory Insufficiency Respiratory Insufficiency Syndrome Of Newborn
Neuroendocrine Tumor	Neuroendocrine Neoplasm Neuroendocrine Tumors Carcinoma, Neuroendocrine
Thyroid Malformation
Solid Adenocarcinoma With Mucin Production
Sex Cord-Gonadal Stromal Tumor	Sex Cord-Gonadal Stromal Tumour Sex Cord Stromal Tumour Sex Cord-Stromal Neoplasm Specialized Gonadal Neoplasm Specialized Gonadal Tumor Specialized Gonadal Tumour Sex Cord-Gonadal Stromal Tumors Sex Cord-Stromal Tumor Malignant Testicular Sex Cord-Stromal Tumor Sex Cord Stromal Tumor Of Testis
Sternum Cancer	Malignant Sternal Neoplasm Neoplasm Of Sternum
Sternum Lymphoma	Lymphoma Of Sternum Lymphoma Of The Sternum
Lung Meningioma	Lung Primary Meningioma Primary Pulmonary Meningioma Pulmonary Meningioma Primary Lung Meningioma
Malignant Struma Ovarii	Struma Ovarii, Malignant
Lung Papillary Adenocarcinoma	Papillary Lung Adenocarcinoma Papillary Adenocarcinoma Of The Lung
Thyroid Carcinoma, Familial Medullary	Medullary Thyroid Carcinoma Familial Medullary Thyroid Carcinoma MTC Medullary Thyroid Cancer Fmtc Mtc1 Thyroid Cancer, Medullary Thyroid Carcinoma, Medullary Familial Mtc Thyroid Carcinoma Medullary Carcinoma, Thyroid, Medullary, Familial Medullary Carcinoma Of Thyroid Medullary Carcinoma With Amyloid Stroma, Unspecified Site Medullary Carcinoma With Amyloid Stroma Of Thyroid
Keratinizing Squamous Cell Carcinoma	Squamous Cell Carcinoma, Keratinizing Keratinizing Epidermoid Carcinoma
Ovarian Germ Cell Cancer	Ovarian Germ Cell Tumor Malignant Germ Cell Tumor Of Ovary Germ Cell Neoplasm Of Ovary Germ Cell Tumor Of Ovary Mogct Malignant Ovarian Germ Cell Tumor Malignant Ovarian Germ Cell Neoplasm
Lung Sarcomatoid Carcinoma	Sarcomatoid Carcinoma Of The Lung Pulmonary Sarcomatoid Carcinoma
Patent Foramen Ovale	Atrial Septal Defect Within Oval Fossa Foramen Ovale Patent Ostium Secundum Atrial Septal Defect Atrial Septal Defect, Ostium Secundum Type Foramen Ovale, Patent Defect, Patent Or Persistent, Ostium Secundum Ostium Secundum Type Atrial Septal Defect Persistent Ostium Secundum Asd Ostium Secundum Type Ostium Secundum Asd Osasd Asd, Ostium Secundum Type Pfo - [Patent Foramen Ovale] Open Foramen Ovale Open Oval Foramen Persistent Foramen Ovale Secundum Atrial Septal Defect
Chordoid Glioma	Chordoid Glioma Of The Third Ventricle
Paraganglioma	Chemodectoma Glomus Body Tumor Paragangliomas Carotid Body Paraganglioma Extra-Adrenal Paraganglioma
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Spindle Epithelial Tumor With Thymus-Like Differentiation Tumor	Settle Tumor Settle Tumour Spindle Epithelial Tumour With Thymus-Like Differentiation Tumour
Lung Acinar Adenocarcinoma	Acinar Adenocarcinoma Of The Lung
Small Cell Carcinoma	Small Cell Carcinoma, Intermediate Cell Intermediate Cell Small Cell Carcinoma Small Cell Carcinoma - Intermediate Cell Small Cell Carcinoma Of Lung Carcinoma, Small Cell
Main Bronchus Cancer	Malignant Neoplasm Of Main Bronchus Ca Main Bronchus
Lung Giant Cell Carcinoma	Carcinoma, Giant Cell Giant Cell Carcinoma Giant Cell Lung Carcinoma Carcinoma Giant Cell Giant Cell Carcinoma Of Lung
Mucinous Adenocarcinoma	Mucin-Producing Adenocarcinoma Mucin-Secreting Adenocarcinoma Mucin-Secreting Carcinoma Mucous Carcinoma Pseudomyxoma Peritonei With Unknown Primary Site Adenocarcinoma, Mucinous
Ureter Small Cell Carcinoma	Ureteral Small Cell Carcinoma
Salivary Gland Carcinoma	Salivary Gland Cancer Malignant Neoplasm Of Salivary Gland Salivary Gland Neoplasms
Pulmonary Neuroendocrine Tumor	Neuroendocrine Neoplasm Of Lung
Lung Carcinoma In Situ
Pulmonary Large Cell Neuroendocrine Carcinoma	Large Cell Lung Neuroendocrine Carcinoma
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Thymus Basaloid Carcinoma	Basaloid Carcinoma Of The Thymus Thymic Basaloid Carcinoma
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Squamous Cell Skin Cancer Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Aortic Malignant Tumor	Aortic Malignant Neoplasm Malignant Aortic Neoplasm
Thymus Clear Cell Carcinoma	Clear Cell Carcinoma Of The Thymus Thymic Clear Cell Carcinoma
Glioblastoma Neural Subtype
Movement Disease	Movement Disorders Movement Disorder
Ureter Adenocarcinoma	Adenocarcinoma Of Ureter Ureteral Adenocarcinoma
Adenocarcinoma In Situ
Choreatic Disease	Chorea Hereditary Chorea
Nasal Cavity Olfactory Neuroblastoma	Olfactory Neuroblastoma Of The Nasal Cavity
Hypothyroidism, Thyroidal Or Athyroidal, With Spiky Hair And Cleft Palate	Bamforth-Lazarus Syndrome Bamforth Syndrome Hypothyroidism, Athyroidal, With Spiky Hair And Cleft Palate Hypothyroidism Cleft Palate Hypothyroidism, Athyroidal, With Spiky Hair And Cleft Palate Athyroidal Hypothyroidism-Spiky Hair-Cleft Palate Syndrome Hypothyroidism-Cleft Palate Syndrome BLS Athyroidal Hypothyroidism With Spiky Hair And Cleft Palate
Tracheal Disease	Tracheal Diseases Tracheal Anomaly Tracheal Disorders
Tall Cell Variant Papillary Carcinoma	Tall Cell Variant Thyroid Gland Papillary Carcinoma
Basaloid Squamous Cell Carcinoma	Basaloid Carcinoma
Thyroid Gland Follicular Carcinoma	Follicular Thyroid Carcinoma Follicular Adenocarcinoma Follicular Adenocarcinoma, Well Differentiated Follicular Carcinoma Thyroid Adenocarcinoma Adenocarcinoma, Follicular
Tracheomalacia	Congenital Tracheomalacia Congenital Major Airway Collapse Tracheomalacia, Congenital Type 1 Tracheomalacia
Pulmonary Adenocarcinoma In Situ	Bronchioalveolar Carcinoma
Cystic Teratoma	Dermoid Cyst Benign Teratoma
Lymphangitis	Inflammation Of Lymphatics
Multinodular Goiter
Ectopic Thymus
Interstitial Lung Disease	Ild Lung Diseases, Interstitial Lung Diseases Interstitial Interstitial Lung Diseases
Thyroid Dyshormonogenesis 2a	TDH2A Iodide Peroxidase Deficiency Deficiency Of Iodide Peroxidase Thyroid Peroxidase Deficiency Genetic Defect In Thyroid Hormonogenesis 2a Thyroid Hormonogenesis, Genetic Defect In, 2a Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2a Chdh2a Congenital Hypothyroidism Due To Dyshormonogenesis Type 2a Thyroid Hormone Organification Defect 2 Tiod
Ovarian Cystic Teratoma
Thyroid Gland Disease	Abnormality Of The Thyroid Gland Thyroid Diseases
Restless Legs Syndrome	Wed Willis-Ekbom Disease Restless Leg Syndrome Ekbom Syndrome Wittmaack-Ekbom Syndrome Willis Ekbom Disease Ekbom'S Syndrome Rls Restless Legs Restless Legs Syndrome, Susceptibility To
Ovary Leiomyosarcoma	Leiomyosarcoma Of Ovary
Mediastinal Cancer	Mediastinal Neoplasms Mediastinal Tumor Mediastinum Cancer Neoplasm Of Mediastinum Tumour Of Mediastinum Malignant Tumor Of Mediastinum
Tracheal Stenosis	Stenosis Of Trachea
Carotid Body Cancer	Cancer Of Carotid Body Malignant Carotid Body Paraganglioma Malignant Carotid Body Tumor Malignant Neoplasm Of Carotid Body
Laryngeal Small Cell Carcinoma	Small Cell Carcinoma Of Larynx
Thyroid Gland Medullary Carcinoma	Medullary Thyroid Carcinoma Medullary Carcinoma Of The Thyroid Gland Ultimobranchial Thyroid Tumor Ultimobranchial Thyroid Tumour Thyroid Cancer, Medullary
Cerebral Palsy	Infantile Cerebral Palsy Mixed Cerebral Palsy Palsy Cerebral Palsy, Cerebral Cerebral Palsy, Mixed
Laryngeal Neuroendocrine Tumor	Laryngeal Neuroendocrine Tumour Neuroendocrine Tumor Of Larynx Neuroendocrine Tumour Of Larynx Neuroendocrine Neoplasm Of Larynx
Retinal Melanoma	Malignant Retinal Melanoma Malignant Melanoma Of Retina
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Lung Clear Cell Carcinoma
Lung Adenoma	Adenoma Of Lung Pulmonary Adenoma
Mixed Lacrimal Gland Cancer	Carcinoma Ex Pleomorphic Adenoma Of Lacrimal Gland Carcinoma Ex Pleomorphic Adenoma Of The Lacrimal Gland Malignant Mixed Neoplasm Of Lacrimal Gland
Lymphohistiocytoid Mesothelioma
Mowat-Wilson Syndrome	MOWS Microcephaly, Mental Retardation, And Distinct Facial Features, With Or Without Hirschsprung Disease Hirschsprung Disease-Mental Retardation Syndrome Mowat-Wilson Syndrome Due To Monosomy 2q22 Hirschsprung Disease Mental Retardation Syndrome Microcephaly, Mental Retardation, And Distinct Facial Featrues, With Or Without Hirschprung Disease Hirschsprung Disease - Intellectual Disability Syndrome Hirschsprung Disease Intellectual Disability Syndrome Intellectual Disability, Microcephaly, And Distinct Facial Features With Or Without Hirschsprung Disease Mws Hirschsprung Disease-Intellectual Disability Syndrome Hirschsprung Disease And Intellectual Disability Due To 2q22 Microdeletion Hirschsprung Disease And Intellectual Disability Due To Del(2)(Q22) Hirschsprung Disease And Intellectual Disability Due To Monosomy 2q22 Mowat-Wilson Syndrome Due To 2q22 Microdeletion Mowat-Wilson Syndrome Due To Del(2)Q(22) Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation Hirschsprung Disease And Intellectual Disability Due To A Zeb2 Point Mutation
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Esophageal Atresia	Tracheoesophageal Fistula Congenital Atresia Of Esophagus Congenital Imperforate Esophagus Imperforate Esophagus Oesophageal Atresia Te Fistula Tef Tracheoesophageal Fistula With Or Without Esophageal Atresia
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Hirschsprung'S Disease Congenital Megacolon Congenital Intestinal Aganglionosis Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W331198	Tralopyril	Inducer	99.70%	Unkown
HY-RS09327	NKX2-1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NKX2-1	MGD	MGI:108067
Rattus norvegicus	NKX2-1	RGD	RGD:3866
Bos taurus	NKX2-1	VGNC	VGNC:49980
Macaca mulatta	NKX2-1	VGNC	VGNC:84409
Felis catus	NKX2-1	VGNC	VGNC:80906
Others	NKX2-1	NCBI