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Cat. No.: HY-123520

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GSK299115A

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GSK299115A is a G Protein-coupled Receptor Kinase (GRK) and PKA inhibitor.

For research use only. We do not sell to patients.

Purity: 98.99%
CAS No.: 864082-35-9
Formula: C₂₀H₁₆Cl₂N₄O₂
Molecular Weight:415.27

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

GSK299115A Chemical Structure

CAS No.: 864082-35-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

GSK299115A is a G Protein-coupled Receptor Kinase (GRK) and PKA inhibitor^[1].

All PKA Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Sf9	IC₅₀	8 nM Compound: 11	Inhibition of human recombinant ROCK1 expressed in Sf9 cells at 10 mM Inhibition of human recombinant ROCK1 expressed in Sf9 cells at 10 mM	[PMID: 17201405]

Chemical Information

CAS No. 864082-35-9
Appearance Solid
Molecular Weight 415.27
Formula C₂₀H₁₆Cl₂N₄O₂
Color White to off-white
SMILES

O=C(NC1=CC2=C(C=C1)NN=C2)C3=C(NC(CC3C4=CC=C(C(Cl)=C4)Cl)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Homan KT, et al. Identification and structure-function analysis of subfamily selective G protein-coupled receptor kinase inhibitors. ACS Chem Biol. 2015 Jan 16;10(1):310-9. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
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Purity & Documentation
References

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GSK299115A

MCE Bioactive Compound Library

All PKA Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

GSK299115A Related Classifications

HY-123520 Related Classifications