Prednimustine
Based on 1 Customer Validation
Prednimustine (Leo 1031;NSC 134087) is the ester formed from Prednisolone (HY-17463) and Chlorambucil (HY-13593). Prednimustine can be used for leukemias and lymphomas research.
For research use only. We do not sell to patients.
- Purity: 95.58%
- CAS No.: 29069-24-7
- Formula: C35H45Cl2NO6
- Molecular Weight:646.64
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Prednimustine (40 mg/kg; s.c.; single dose) produces low plasma concentrations (less than 5 microM) of the alkylating metabolites chlorambucil and phenyl acetic mustard, which were maintained for 48 h in rats bearing the sensitive strain of the Walker 256 carcinosarcoma grown as an ascites[1].
Prednimustine (40 mg/kg;s.c.; single dose; measured at 72 h) shows antitumor effect in rats model with the alkylating agent-resistant strain of the Yoshida sarcoma[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Wistar rats non-tumour-bearing (150-200g)[1]
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Dosage:120 mg/kg
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Administration:Subcutaneous injection; single dose; observed at day 21
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Result:Remained 100% survival of rats, while 0% survival for Chlorambucil treatment group.
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Animal Model:Female Wistar rats bearing the alkylating agent-resistant strain of the Yoshida sarcoma (150-200g)[1]
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Dosage:40 mg/kg
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Administration:Subcutaneous injection; single dose
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Result:Killed 57% of the resistant tumour cells.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 29069-24-7
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Appearance Solid
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Molecular Weight 646.64
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Formula C35H45Cl2NO6
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Color White to light yellow
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SMILES
C[C@@]12[C@](C(COC(CCCC3=CC=C(N(CCCl)CCCl)C=C3)=O)=O)(O)CC[C@@]1([H])[C@]4([H])CCC5=CC(C=C[C@]5(C)[C@@]4([H])[C@@H](O)C2)=O
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Synonyms
Leo 1031; NSC 134087
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (154.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.5465 mL | 7.7323 mL | 15.4646 mL | 38.6614 mL |
| 5 mM | 0.3093 mL | 1.5465 mL | 3.0929 mL | 7.7323 mL | |
| 10 mM | 0.1546 mL | 0.7732 mL | 1.5465 mL | 3.8661 mL | |
| 15 mM | 0.1031 mL | 0.5155 mL | 1.0310 mL | 2.5774 mL | |
| 20 mM | 0.0773 mL | 0.3866 mL | 0.7732 mL | 1.9331 mL | |
| 25 mM | 0.0619 mL | 0.3093 mL | 0.6186 mL | 1.5465 mL | |
| 30 mM | 0.0515 mL | 0.2577 mL | 0.5155 mL | 1.2887 mL | |
| 40 mM | 0.0387 mL | 0.1933 mL | 0.3866 mL | 0.9665 mL | |
| 50 mM | 0.0309 mL | 0.1546 mL | 0.3093 mL | 0.7732 mL | |
| 60 mM | 0.0258 mL | 0.1289 mL | 0.2577 mL | 0.6444 mL | |
| 80 mM | 0.0193 mL | 0.0967 mL | 0.1933 mL | 0.4833 mL | |
| 100 mM | 0.0155 mL | 0.0773 mL | 0.1546 mL | 0.3866 mL |
Prednimustine Related Classifications
HY-13732 Related Classifications
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