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Cat. No.: HY-19887

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Tilapertin

Name: Tilapertin
Brand: MedChemExpress
SKU: HY-19887
Availability: PreOrder

(Synonyms: AMG747)

Tilapertin is an oral inhibitor of glycine transporter type-1 (GlyT1).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1000690-85-6
화학식: C₂₀H₂₁F₃N₂O₂
분자량:378.39

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Tilapertin Chemical Structure

CAS No.: 1000690-85-6

사이즈

가격

재고

수량

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
- Clinical Trial
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Tilapertin is an oral inhibitor of glycine transporter type-1 (GlyT1).

IC₅₀ & Target

GlyT1

All GlyT Isoforms :

GlyT1
GlyT2

In Vivo

Tilapertin is a nanomolar potent, orally bioavailable and selective GlyT1 inhibitor. Oral administration of Tilapertin dose-dependently increases cerebrospinal fluid (CSF) glycine concentration in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1000690-85-6
분자량 378.39
화학식 C₂₀H₂₁F₃N₂O₂
SMILES

O=C(O)CN1CCN([C@H](C2=CC=CC=C2)C3=CC=CC(C(F)(F)F)=C3)CC1
Synonyms

AMG747
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dunayevich E, et al. Efficacy and safety of the glycine transporter type-1 inhibitor AMG 747 for the treatment of negative symptoms associated with schizophrenia. Schizophr Res. 2017 Apr;182:90-97. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
- Clinical Trial
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
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Purity:
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Tilapertin

Bitopertin

Bitopertin (R enantiomer)

Bitopertin (Standard)

GlyT1 Inhibitor 1

LY2365109 hydrochloride

Iclepertin

Org 25543 hydrochloride

(Rac)-ALX 5407

LY2365109 hydrochloride (Standard)

PF-03463275

ASP2535

SSR504734

All GlyT Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Bioz

Tilapertin

Bitopertin

Bitopertin (R enantiomer)

Bitopertin (Standard)

GlyT1 Inhibitor 1

LY2365109 hydrochloride

Iclepertin

Org 25543 hydrochloride

(Rac)-ALX 5407

LY2365109 hydrochloride (Standard)

PF-03463275

ASP2535

SSR504734

All GlyT Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Tilapertin Related Classifications

HY-19887 Related Classifications

Bioz