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Cat. No.: HY-165546

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AGI-16903

AGI-16903 is a metabolite of Enasidenib (HY-18690). Enasidenib is an orally available, reversible, and selective inhibitor of mutant IDH2 enzymes, with IC₅₀ values of 100 nM and 400 nM against IDH2^R140Q and IDH2^R172K, respectively.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1643852-84-9
화학식: C₁₅H₉F₆N₇
분자량:401.28

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

AGI-16903 Chemical Structure

CAS No.: 1643852-84-9

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

Chemical Information

CAS No. 1643852-84-9
분자량 401.28
화학식 C₁₅H₉F₆N₇
SMILES

FC(F)(F)C1=NC(=CC=C1)C=2N=C(N=C(N2)NC=3C=CN=C(C3)C(F)(F)F)N
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocol

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Jeremy Travins, et al. N,6-bis(aryl or heteroaryl)-1,3,5-triazine-2,4-diamine compounds as idh2 mutants inhibitors for the treatment of cancer. WO2015006592A1. 2016-01-11

[2]. Dittakavi S, et al. Validated LC-MS/MS Method for Simultaneous Quantitation of Enasidenib and its Active Metabolite, AGI-16903 in Small Volume Mice Plasma: Application to a Pharmacokinetic Study. Drug Res (Stuttg). 2020;70(1):41-48. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Molecular Weight Molecular Weight

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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