Anticancer agent 25
Anticancer agent 25 is an anticancer agent. Anticancer agent 25 can arrest the cell cycle at the G1 phase, and significantly inhibit tumor cell colony forming and migration even at low concentrations. Anticancer agent 25 can significantly induce cytoplasmic vacuolation. Anticancer agent 25 can be used for the study of prostate cancer, breast cancer, and colon cancer.
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- CAS No.: 2401013-08-7
- 화학식: C37H45BrN2O3
- 분자량:645.67
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Cycle/DNA Damage 0.19 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
0.74 μM
Compound: 18e
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Antiproliferative activity against human DU145 cells assessed as cell growth inhibition by SRB assay
Antiproliferative activity against human DU145 cells assessed as cell growth inhibition by SRB assay
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[PMID: 31812467] |
| HCT-116 | IC50 |
0.55 μM
Compound: 18e
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Antiproliferative activity against human HCT116 cells assessed as cell growth inhibition by SRB assay
Antiproliferative activity against human HCT116 cells assessed as cell growth inhibition by SRB assay
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[PMID: 31812467] |
| HT-29 | IC50 |
0.56 μM
Compound: 18e
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Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition by SRB assay
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition by SRB assay
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[PMID: 31812467] |
| MDA-MB-231 | IC50 |
1.31 μM
Compound: 18e
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Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition by SRB assay
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition by SRB assay
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[PMID: 31812467] |
| PC-3 | IC50 |
0.19 μM
Compound: 18e
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Antiproliferative activity against human PC3 cells assessed as cell growth inhibition by SRB assay
Antiproliferative activity against human PC3 cells assessed as cell growth inhibition by SRB assay
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[PMID: 31812467] |
Anticancer agent 25 (Compound 18e) shows antiproliferative activity against prostate cancer cell lines, PC3 (IC50 = 0.19 μM) and DU145 (IC50 = 0.74 μM); breast cancer cell line MDA-MB-231 (IC50 = 1.31 μM); and human colon cancer cell lines, HT29 (IC50 = 0.56 μM) and HCT116 (IC50 = 0.55 μM); and exhibits low toxicity against normal human aortic fibroblasts (HAF) (IC50 = 3.95 μM)[1].
Anticancer agent 25 (0.5-2 μM, 24 h) induces G1 phase arrest in PC3 cells in a dose-dependent manner[1].
Anticancer agent 25 (0.1-2 μM, 24 h) can significantly inhibit the long-term proliferation ability of PC3 tumor cells even at extremely low concentrations[1].
Anticancer agent 25 (0.1-2 μM, 24 h) significantly and in a dose-dependent manner inhibits the migration ability of PC3 cells[1].
Anticancer agent 25 (0.5-1 μM, 24 h) can induce significant cytoplasmic vacuolation in PC3 cells even at low concentrations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC3 cells
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Concentration:0.5 μM, 1 μM, 2 μM
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Incubation Time:24 h
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Result:Caused ~ 50% inhibition on the colony forming at 0.1 μM and ~ 90% inhibition at 0.5 μM.
Chemical Information
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CAS No. 2401013-08-7
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분자량 645.67
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화학식 C37H45BrN2O3
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SMILES
CC(C)C(C=C1)=CC=C1CC2=C3C=CC(OC)=C(NCCCCCCCC)C3=C[N+]4=C2C5=CC6=C(C=C5CC4)OCO6.[Br-]
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 25 Related Classifications
HY-143641 Related Classifications
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