AP736
AP736 is a potent tyrosinase inhibitor (IC50 = 0.9 μM) with anti-melanogenesis activity in normal human melanocytes (IC50 = 0.11 μM). AP736 suppresses the expression of tyrosinase and TRP-1/2 by inhibiting the cAMP-PKA-CREB signalling axis, leading to reduced microphthalmia-associated transcription factor (MITF) transcripts and proteins. AP736 can be used for melanogenesis and hyperpigmentation research.
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- CAS No.: 1365531-21-0
- 화학식: C26H31NO5
- 분자량:437.53
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16 | IC50 |
1.1 μM
Compound: 3c
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Antimelanogenic activity in mouse B16 cells assessed as inhibition of melanogenesis
Antimelanogenic activity in mouse B16 cells assessed as inhibition of melanogenesis
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[PMID: 22300660] |
Chemical Information
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CAS No. 1365531-21-0
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분자량 437.53
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화학식 C26H31NO5
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SMILES
O=C(C1=C(OC)C=C(OC)C(C23CC4CC(C3)CC(C2)C4)=C1)NCC5=CC=C(C=C5O)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Shin HJ, et al. Development and evaluation of topical formulations for a novel skin whitening agent (AP736) using Hansen solubility parameters and PEG-PCL polymers. Int J Pharm. 2018 Dec 1;552(1-2):251-257. [Content Brief]
[2]. Lee CS, et al. A novel adamantyl benzylbenzamide derivative, AP736, suppresses melanogenesis through the inhibition of cAMP-PKA-CREB-activated microphthalmia-associated transcription factor and tyrosinase expression. Exp Dermatol. 2013 Nov;22(11):762-4. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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