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Cat. No.: HY-114440

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Belapectin

(Synonyms: GR-MD-02)

고객리뷰

Based on 1 Customer Validation

Belapectin (GR-MD-02) is a Galectin-3 (Gal-3) inhibitor. Belapectin drives tumor-induced immunosuppression by inducing T cell Apoptosis. Belapectin promotes tumor regression and improves survival of tumor-bearing mice through a CD8+ T cell-dependent mechanism. Belapectin binds to Gal-3 with affinity K_i of 2.8 μM.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 98.94%
CAS No.: 1980787-47-0

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Belapectin Chemical Structure

CAS No.: 1980787-47-0

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재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
용액&용해도
- In Vitro
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

Galectin-3

All Galectin Isoforms :

In Vitro

Belapectin (0.2 mg/mL, 2 mg/mL; 48 h) inhibits the proliferation of 4T1 and MCA-205 cells and induced apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

TRAMP-C1, 4T1 and MCA-205 cells
Concentration:

0.2 mg/mL, 2 mg/mL
Incubation Time:

48 h
Result:

Decreased the proliferation and resulted a minimal increase in apoptosis of 4T1 and MCA-205 cells. But showed no impact on TRAMP-C1 cell.

In Vivo

Belapectin (2.4 mg/mouse; i.p.; 3 times per week for 3 weeks) only exerts function under the combination with anti-OX40 mAb, does cause a significant reduction in tumor growth and a corresponding increase in survival. The combined treatment also produces lasting long-term memory, and 100 percent of the tumor-free mice were protected from subsequent tumor reattacks^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wild-type C57BL/6 and BALB/c mice^[1]
Dosage:

2.4 mg/mouse, accompanied with anti-OX40 mAb (250 µg)
Administration:

Intraperitoneal injection; 3 times per week for 3 weeks
Result:

Inhibited tumor growth.
Enhanced the efficacy of checkpoint blockade (aPD-L1) immunotherapy.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1980787-47-0
Appearance Solid
Color White to off-white
SMILES

[Belapectin]
Synonyms

GR-MD-02
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

H₂O : 10 mg/mL (ultrasonic and warming and heat to 60°C)

View the Complete Stock Solution Preparation Table

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sturgill ER, et al. Galectin-3 inhibition with belapectin combined with anti-OX40 therapy reprograms the tumor microenvironment to favor anti-tumor immunity. Oncoimmunology. 2021 Mar 1;10(1):1892265. [Content Brief]

[2]. Capasso D, et al. Galectins detection for the diagnosis of chronic diseases: An emerging biosensor approach[J]. TrAC Trends in Analytical Chemistry, 2023: 116952.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
용액&용해도
- In Vitro
순도&문서
References

상품명:
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Belapectin

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

All Galectin Isoforms

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Calculators

Help & FAQs

Belapectin

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

All Galectin Isoforms

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Calculators

Help & FAQs

Belapectin Related Classifications

HY-114440 Related Classifications