BIO-8169
BIO-8169 is a selective inhibitor for interleukin receptor-associated kinase 4 (IRAK 4), with an IC50 of 0.23 nM. BIO-8169 exhibits good pharmacokinetic character, reduces the production of pro-inflammatory cytokines, and attenuates the autoimmune encephalomyelitis in EAE mice model. BIO-8169 exhibits good blood brain penetrant with a rat Kpu,u of 0.7.
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- CAS No.: 2792153-06-9
- 화학식: C24H27N5O4
- 분자량:449.50
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Help & FAQs
Biological Activity
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IRAK4 0.23 nM (IC50) |
Chemical Information
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CAS No. 2792153-06-9
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분자량 449.50
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화학식 C24H27N5O4
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SMILES
CC(OC1=NC2=NC(C34COC(C3)(C4)C)=CN2C=C1C(NC5=CC=CN(C5=O)C6CC6)=O)C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BIO-8169 Related Classifications
HY-158374 Related Classifications
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