CAII-IN-12
CAII-IN-12 (compound 6c) is a potent and selective carbonic anhydrase (CA) II and VII inhibitor (hCA II Ki = 47.8 nM, hCA VII Ki = 3.6 nM) with anti-epilepitic activity. CAII-IN-12 displays selectivity over hCA I (Ki = 370 nM). CAII-IN-12 exhibits potent anticonvulsant activity in both Pentylenetetrazol- and Pilocarpine (HY-B0726A)-induced seizure mouse models. CAII-IN-12 increases expression of KCC2 in the hippocampus, maintains neuronal integrity, and reduces mTOR activity. CAII-IN-12 can be used for epilepsy research.
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- 화학식: C19H16N4O7S2
- 분자량:476.48
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[1]|
hCA II 47.8 nM (Ki) |
hCA VII 3.6 nM (Ki) |
hCA I 370 nM (Ki) |
Chemical Information
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분자량 476.48
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화학식 C19H16N4O7S2
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SMILES
O=C(NC1=CC=C(S(=O)(N)=O)C=C1)CCN(C/2=O)C(SC2=C/C3=CC=C([N+]([O-])=O)C=C3)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CAII-IN-12 Related Classifications
HY-180056 Related Classifications
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