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Cat. No.: HY-125790

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Cyclazocine

Cyclazocine is a μ, δ, and κ opioid receptor modulator with K_i values of 0.32, 1.1, and 0.18 nM, respectively. Cyclazocine exhibits "mixed" pharmacological activities, acting as a μ-partial antagonist, κ-agonist, and low-affinity δ ligand. Cyclazocine shows antinociceptive activity in mice. Cyclazocine can be used in studies on psychoactive substance addiction.

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CAS No.: 3572-80-3
화학식: C₁₈H₂₅NO
분자량:271.40

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Cyclazocine Chemical Structure

CAS No.: 3572-80-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
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References
Calculators
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Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

μ Opioid Receptor/MOR

0.32 nM (Ki)

κ Opioid Receptor/KOR

1.1 nM (Ki)

δ Opioid Receptor/DOR

0.18 nM (Ki)

All Opioid Receptor Isoforms :

In Vitro

Cyclazocine potently binds to μ, δ, and κ opioid receptors in guinea pig brain cell membranes, with K_i values of 0.32 nM, 1.1 nM, and 0.18 nM, respectively^[1].
Cyclazocine potently binds to the human μ-opioid receptor stably expressed in CHO cells, with a K_i value of 0.16 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cyclazocine (1 mg/kg; i.p.; single dose) administered in mice exhibits antinociceptive activity with a 2-hour duration of action^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3572-80-3
분자량 271.40
화학식 C₁₈H₂₅NO
SMILES

OC1=CC=C2C(C3(CCN(C(C3C)C2)CC4CC4)C)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Wentland MP, et al. Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 3: 8-Thiocarboxamido and 8-thioformamido derivatives of cyclazocine. Bioorg Med Chem Lett. 2005;15(10):2547-2551. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

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Cyclazocine

All Opioid Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Cyclazocine Related Classifications

HY-125790 Related Classifications