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Cat. No.: HY-120730

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DA 1686

DA 1686 is an orally active naphthalene derivative that induces bradycardia and mild hypotension. DA 1686 can be used in the study of arrhythmias.

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CAS No.: 13071-27-7
화학식: C₂₃H₃₂N₂O₂
분자량:368.51

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

DA 1686 Chemical Structure

CAS No.: 13071-27-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

DA 1686 is an orally active naphthalene derivative that induces bradycardia and mild hypotension. DA 1686 can be used in the study of arrhythmias^[1].

In Vitro

DA 1686 reduces aconitine-induced tachycardia and responsiveness to increased electrical stimulation in isolated guinea-pig auricles^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DA 1686 exhibits local anaesthetic activity in in vivo mouse and guinea-pig models^[1].
DA 1686 (20 mg/kg; i.v.; slow infusion) protects anaesthetized dogs from Adrenaline (HY-B0447)-induced death during benzol inhalation^[1].
DA 1686 protects rats from arrhythmia induced by intravenous administration of 34 μg/kg Aconitine^[1].
DA 1686 delays the onset of Ouabain (HY-B1457)-induced arrhythmia, ventricular fibrillation, and cardiac arrest in guinea-pigs^[1].
DA 1686 reduces tachycardia induced by 10 days of daily 0.2 mg Thyroxine (HY-18341) administration in rabbits^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Dog^[1]
Dosage:

20 mg/kg
Administration:

i.v.; slow infusion
Result:

Protected anaesthetized dogs from death induced by rapid intravenous adrenaline administration during benzol inhalation.

Chemical Information

CAS No. 13071-27-7
분자량 368.51
화학식 C₂₃H₃₂N₂O₂
SMILES

N1(CCC(CCN2CCOCC2)C3=CC=CC4=C3C=CC=C4)CCOCC1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bianchi C, et al. Anti-arrhythmic properties of 1,5-dimorpholino-3-(1-naphthyl)-pentane (DA 1686). Arzneimittelforschung. 1968 Jul;18(7):845-50. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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