DIX-01

DIX-01 (1-2000 nM; 2-18 h) induces proteasome-dependent, concentration- and time-dependent degradation of IKZF1, IKZF3, and GSPT1 in human acute myeloid leukemia MV4-11 cells with DC₅₀ values of 19.80 nM, 45.31 nM, and 120.1 nM, respectively, while sparing CK1α and causing no change in Axin levels^[1].
DIX-01 (1 μM; 16 h) induces substantial degradation of IKZF1, IKZF3, GSPT1, Axin, and β-catenin in human acute myeloid leukemia MV4-11 cells^[1].
DIX-01 (100 nM; 6 h) significantly reduces IKZF1 and GSPT1 protein levels in human acute myeloid leukemia MV4-11 cells, as confirmed by quantitative proteomic analysis^[1].
DIX-01 (0.1-100 nM; 72 h) has minimal effect on the cell cycle distribution of human acute myeloid leukemia MV4-11 cells at 0.1 nM and 10 nM after 72 h, but causes a significant shift toward cell debris at 100 nM^[1].
DIX-01 (100 nM; 6 h) modulates immune-related signaling pathways and cytoplasmic translation processes in human acute myeloid leukemia MV4-11 cells, with no significant impact on IKZF1/3 gene transcription^[1].
DIX-01 (0.1-100 nM; 72 h) induces concentration-dependent apoptosis in human acute myeloid leukemia MV4-11 cells, with 94.8% of cells undergoing apoptosis at 100 nM after 72 h of treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.