Ferfluor-1
Based on 1 Customer Validation
Ferfluor-1 is a Ferroptosis inhibitor (EC50 of 57 nM in HT108 cells; EC50 of 75 nM in OS-RC-2 cells; EC50 of 2.3 nM in SH-SY5Y neuroblastoma cells), and ratiometric photoluminescent probe with blood-brain barrier permeability. Ferfluor-1 is a specific indicator for the fluctuation of Ferroptosis. Ferfluor-1 alleviates brain disorder diseases of in vivo stroke and PD models.
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- Purity: 99.33%
- CAS No.: 3030473-59-4
- 화학식: C15H20N4S
- 분자량:288.41
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
Ferfluor-1 potently inhibits ferroptosis in HT1080 fibrosarcoma cells with an EC50 of 57 nM, in OS-RC-2 renal carcinoma cells with an EC50 of 75 nM, and in SH-SY5Y neuroblastoma cells with an EC50 of 2.3 nM[1].
Ferfluor-1 (5 μM) does not inhibit Staurosporine (HY-15141)-induced apoptosis in SH-SY5Y neuroblastoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (male)[1]
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Dosage:10 mg/kg
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Administration:i.v.; single administration
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Result:Substantially decreased cerebral infarction volume compared to the vehicle control.
Reduced the proportion of infarcted tissue compared to the vehicle control.
Improved blood flow in ischemic brain tissue compared to the vehicle control.
Significantly decreased PTGS2 gene expression in the lesioned hemisphere compared to the vehicle control.
Reduced malondialdehyde (MDA) levels in the lesioned hemisphere relative to the vehicle control.
Showed no obvious toxicity in major organs (heart, liver, spleen, lung, kidney) via histopathological staining.
Chemical Information
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CAS No. 3030473-59-4
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Appearance Solid
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분자량 288.41
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화학식 C15H20N4S
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Color Light yellow to yellow
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SMILES
NC1=C(NC2CCCCC2)C=CC(C3=NN=C(C)S3)=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
용액&용해도
DMSO : ≥ 250 mg/mL (866.82 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4673 mL | 17.3364 mL | 34.6729 mL | 86.6822 mL |
| 5 mM | 0.6935 mL | 3.4673 mL | 6.9346 mL | 17.3364 mL | |
| 10 mM | 0.3467 mL | 1.7336 mL | 3.4673 mL | 8.6682 mL | |
| 15 mM | 0.2312 mL | 1.1558 mL | 2.3115 mL | 5.7788 mL | |
| 20 mM | 0.1734 mL | 0.8668 mL | 1.7336 mL | 4.3341 mL | |
| 25 mM | 0.1387 mL | 0.6935 mL | 1.3869 mL | 3.4673 mL | |
| 30 mM | 0.1156 mL | 0.5779 mL | 1.1558 mL | 2.8894 mL | |
| 40 mM | 0.0867 mL | 0.4334 mL | 0.8668 mL | 2.1671 mL | |
| 50 mM | 0.0693 mL | 0.3467 mL | 0.6935 mL | 1.7336 mL | |
| 60 mM | 0.0578 mL | 0.2889 mL | 0.5779 mL | 1.4447 mL | |
| 80 mM | 0.0433 mL | 0.2167 mL | 0.4334 mL | 1.0835 mL | |
| 100 mM | 0.0347 mL | 0.1734 mL | 0.3467 mL | 0.8668 mL |
Ferfluor-1 Related Classifications
HY-185056 Related Classifications
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- Ferfluor-1
- 3030473-59-4
- Ferfluor1
- Ferfluor 1
- Ferroptosis
- Fluorescent Dye
- phospholipid peroxidation
- OS-RC-2 renal carcinoma cells
- ferroptosis
- phospholipid hydroperoxides
- Parkinson’s disease
- HT1080 fibrosarcoma cells
- stroke
- blood-brain barrier
- SH-SY5Y neuroblastoma cells
- endoplasmic reticulum
- Inhibitor
- inhibitor
- inhibit