FMAU
Based on 1 Customer Validation
FMAU is a nucleoside analog and cell proliferation marker that can be phosphorylated by human thymidine kinase and subsequently incorporated into DNA. FMAU is applicable to research related to herpes simplex virus infection, various cancers, hepatitis B virus infection, and Epstein-Barr virus infection.
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- Purity: 99.04%
- CAS No.: 69256-17-3
- 화학식: C10H13FN2O5
- 분자량:260.22
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | IC50 |
>200 μM
Compound: 13
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The growth inhibition activity for the compound was evaluated in CEM cells.
The growth inhibition activity for the compound was evaluated in CEM cells.
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[PMID: 8709113] |
| HepG2 2.2.15 | EC50 |
0.1 μM
Compound: 13
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Anti hepatitis-B virus activity was evaluated in 2.2.15 cells.
Anti hepatitis-B virus activity was evaluated in 2.2.15 cells.
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[PMID: 8709113] |
| HepG2 2.2.15 | IC50 |
>200 μM
Compound: 13
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The growth inhibition activity for the compound was evaluated in 2.2.15 cells.
The growth inhibition activity for the compound was evaluated in 2.2.15 cells.
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[PMID: 8709113] |
| HL-60 | IC50 |
>1 mM
Compound: 14
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Inhibition of human promyelocytic leukemic cell (HL-60) by XXT-microculture tetrazolium assay
Inhibition of human promyelocytic leukemic cell (HL-60) by XXT-microculture tetrazolium assay
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[PMID: 2033590] |
| HL-60 | IC50 |
>1 mM
Compound: 14
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Inhibition of human promyelocytic leukemic cell (HL-60) trypan blue exclusion assay
Inhibition of human promyelocytic leukemic cell (HL-60) trypan blue exclusion assay
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[PMID: 2033590] |
| Vero | ED50 |
0.018 μM
Compound: 1a
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Compound was tested for antiviral activity against Herpes simplex virus-1 (Strain F) in vero cells by plaque reduction assay.
Compound was tested for antiviral activity against Herpes simplex virus-1 (Strain F) in vero cells by plaque reduction assay.
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[PMID: 3001306] |
| Vero | ED50 |
0.023 μM
Compound: 1a
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Compound was tested for antiviral activity against Herpes simplex virus-2 (Strain G) in vero cells by plaque reduction assay.
Compound was tested for antiviral activity against Herpes simplex virus-2 (Strain G) in vero cells by plaque reduction assay.
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[PMID: 3001306] |
[18F]D-FMAU (20 μCi/2 mL; 15-240 min) exhibits significant time-dependent uptake in HSV1-TK gene-expressing MCA-TK cells, with a relative uptake ratio (MCA-TK/MCA) of 70 after 240 min of incubation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Radiolabeled D-FMAU achieves higher total tumor uptake than its L-isomer in human non-small cell lung cancer xenografts in nude mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 69256-17-3
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Appearance Solid
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분자량 260.22
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화학식 C10H13FN2O5
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Color White to off-white
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SMILES
O[C@H]1[C@H](F)[C@H](N(C(N2)=O)C=C(C)C2=O)O[C@@H]1CO
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Synonyms
D-FMAU
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 125 mg/mL (480.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8429 mL | 19.2145 mL | 38.4290 mL | 96.0726 mL |
| 5 mM | 0.7686 mL | 3.8429 mL | 7.6858 mL | 19.2145 mL | |
| 10 mM | 0.3843 mL | 1.9215 mL | 3.8429 mL | 9.6073 mL | |
| 15 mM | 0.2562 mL | 1.2810 mL | 2.5619 mL | 6.4048 mL | |
| 20 mM | 0.1921 mL | 0.9607 mL | 1.9215 mL | 4.8036 mL | |
| 25 mM | 0.1537 mL | 0.7686 mL | 1.5372 mL | 3.8429 mL | |
| 30 mM | 0.1281 mL | 0.6405 mL | 1.2810 mL | 3.2024 mL | |
| 40 mM | 0.0961 mL | 0.4804 mL | 0.9607 mL | 2.4018 mL | |
| 50 mM | 0.0769 mL | 0.3843 mL | 0.7686 mL | 1.9215 mL | |
| 60 mM | 0.0640 mL | 0.3202 mL | 0.6405 mL | 1.6012 mL | |
| 80 mM | 0.0480 mL | 0.2402 mL | 0.4804 mL | 1.2009 mL | |
| 100 mM | 0.0384 mL | 0.1921 mL | 0.3843 mL | 0.9607 mL |
FMAU Related Classifications
HY-114247 Related Classifications
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