IFNGR1 - interferon gamma receptor 1 Gene

Also Known as CD119; IFNGR; IMD27A; IMD27B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3459

About IFNGR1

Cytogenetic location: 6q23.3 Genomic coordinates (GRCh38): 6:137,197,484-137,219,385 (from NCBI)

This gene has 19 transcripts (splice variants), 308 orthologues, 11 paralogues and is associated with 9 phenotypes. Ubiquitous expression in spleen (RPKM 51.4), fat (RPKM 48.1) and 25 other tissues.

Summary

This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori Infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial Infection. [provided by RefSeq, Jul 2008]

IFNGR1 Products (3)

mRNA	Protein	Name
NM_000416.3	NP_000407.1	interferon gamma receptor 1 isoform 1 precursor
NM_001363526.1	NP_001350455.1	interferon gamma receptor 1 isoform 2
NM_001363527.1	NP_001350456.1	interferon gamma receptor 1 isoform 3

IFNGR1 Protein Structure

Tissue_fac

IFNGR1

0
100
200
300
400
489 a.a.

Protein Preferred Names	Protein Names
interferon gamma receptor 1	AVP, type 2

IFNGR1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IFNGR1	P15260	IFNG	Homo sapiens	P01579	X-Ray Diffraction	11250200
Intra	IFNGR1	P15260	NINJ2	Homo sapiens	Q9NZG7	Validated Y2H	32296183
Intra	IFNGR1	P15260	STAT1	Homo sapiens	P42224	CoIP	8156998
Intra	IFNGR1	P15260	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	IFNGR1	P15260	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	IFNGR1	P15260	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	IFNGR1	P15260	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	IFNGR1	P15260	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	IFNGR1	P15260	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	IFNGR1	P15260	SLC9A6	Homo sapiens	Q92581-2	Validated Y2H	32296183
Intra	IFNGR1	P15260	SLC9A6	Homo sapiens	Q92581-2	Y2H Array	32296183
Intra	IFNGR1	P15260	SLC9A6	Homo sapiens	Q92581-2	Y2H Prey Pooling	32296183
Intra	IFNGR1	P15260	STIM1	Homo sapiens	Q13586	Y2H Prey Pooling	32296183
Intra	IFNGR1	P15260	STIM1	Homo sapiens	Q13586	Validated Y2H	32296183
Intra	IFNGR1	P15260	STIM1	Homo sapiens	Q13586	Y2H Array	32296183
Intra	IFNGR1	P15260	RUSF1	Homo sapiens	Q96GQ5	Validated Y2H	32296183
Intra	IFNGR1	P15260	TMEM100	Homo sapiens	Q9NV29	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IFNGR1 Proteins

Cat. No.	상품명	Accession	Purity
HY-P72612	IFN-gamma R1/CD119 Protein, Human (HEK293, His, solution)	P15260-1 (E18-G245)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74855	IFN-gamma R1/CD119 Protein, Human (HEK293, hFc)	P15260-1/AAH05333 (E18-G245)	≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
HY-P72612A	IFN-gamma R1/CD119 Protein, Human (HEK293, His)	P15260-1/NP_000407.1 (E18-G245)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700611	IFN-gamma R1/CD119 Protein, Human (HEK293, His-Flag)	P15260-1 (E18-G245)	≥ 90%, as determined by reducing SDS-PAGE.

IFNGR1 Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P82329	IFNGR1 Antibody (YA2074)	WB, IHC-P, ICC/IF, FC	Human
HY-P84109	IFNGR1 Antibody (YA3806)	WB, ICC/IF, FC, ELISA	Human
HY-P84109A	IFNGR1 Antibody (YA3806)(PBS only)	WB, FC, ELISA	Human
HY-P84110	IFNGR1 Antibody (YA3807)	ICC/IF, FC, ELISA	Human
HY-P84110A	IFNGR1 Antibody (YA3807)(PBS only)	ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Immunodeficiency 27a	IMD27A Autosomal Recessive Ifngr1 Deficiency Autosomal Recessive Immunodeficiency 27a, Mycobacteriosis Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency Autosomal Recessive Msmd Due To Partial Ifngammar1 Deficiency Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency Immunodeficiency 27a, Mycobacteriosis, Autosomal Recessive Ifngr1 Deficiency, Autosomal Recessive Immunodeficiency 27a, Mycobacteriosis, Ar Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar1 Deficiency Msmd Due To Complete Ifngammar1 Deficiency Msmd Due To Complete Interferon Gamma Receptor 1 Deficiency Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 1 Deficiency Familial Disseminated Atypical Mycobacterial Infection Interferon Gamma, Receptor 1, Deficiency Immunodeficiency, Type 27a, Mycobacteriosis, Ar Mycobacterial Disease, Mendelian Susceptibility To
Immunodeficiency 27b	Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency IMD27B Immunodeficiency 27b, Mycobacteriosis, Autosomal Dominant Ifngr1 Deficiency, Autosomal Dominant Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency Autosomal Dominant Msmd Due To Partial Ifngammar1 Deficiency Autosomal Dominant Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency Immunodeficiency 27b, Mycobacteriosis, Ad Autosomal Dominant Ifngr1 Deficiency Autosomal Dominant Immunodeficiency 27b, Mycobacteriosis Immunodeficiency, Type 27b, Mycobacteriosis, Autosomal Dominant
Helicobacter Pylori Infection	Helicobacter Pylori Infection, Susceptibility To H. Pylori Infection, Susceptibility To H. Pylori Infection Helicobacter Pylori Infections
Atypical Mycobacteriosis, Familial	Msmd Atypical Mycobacterial Infection, Disseminated Mendelian Susceptibility To Mycobacterial Diseases Idiopathic Infection Caused By Bcg Or Atypical Mycobacteria Mendelian Susceptibility To Atypical Mycobacteria Mendelian Susceptibility To Mycobacterial Infections Disseminated Atypical Mycobacterial Infection Atypical Mycobacterial Infection, Familial Disseminated Mycobacterial Disease, Mendelian Susceptibility To
Interferon Gamma, Receptor 1, Deficiency	Ifngr1 Deficiency Interferon Gamma Receptor 1 Deficiency
Salmonellosis	Salmonella Infections Salmonella Infection
Typhoid Fever	Typhoid Enteric Fever Typhoidal Salmonellosis Ileotyphus Infection By Salmonella Typhi Typhoid Any Site Typhoid Fever Any Site Typhoid Infection Typhoid Infection Any Site Typhoid Fever Confirmed Enteric Fever Nos
Osteomyelitis
Hepatitis B	Chronic Hepatitis B Hepatitis B Infection Serum Hepatitis HBV Hepatitis B Chronic Hbv, Susceptibility To Hepatitis B, Chronic Chronic Hepatitis B Without Delta Agent Chronic Hbv - [Hepatitis B Virus] Infection Hepatitis B Nos Chronic Type B Viral Hepatitis Hep B Nos
Coccidioidomycosis	Valley Fever Primary Extrapulmonary Coccidioidomycosis Coccidioides Immitis Infection Coccidiosis Coccidioides Infection Coccidioidomycosis, Unspecified San Joaquin Fever California Disease Desert Fever Desert Rheumatism San Joaquin Valley Fever Enteric Coccidiosis Primary Pulmonary Coccidioidomycosis Acute Coccidioidomycosis Posadas Wernicke Disease
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behçet'S Disease Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Pulmonary Tuberculosis	Tuberculosis, Pulmonary PTB Tuberculosis Pulmonary
Paratyphoid Fever	Paratyphoid B Fever Paratyphoid C Fever Paratyphoid Fever A Paratyphoid Fever B Paratyphoid Fever C Paratyphoid Paratyphoid A Paratyphoid A Fever Paratyphoid B Paratyphoid C Infection Due To Salmonella Paratyphi
Schistosomiasis	Katayama Fever Bilharzia Bilharziasis Schistosomiasis Mansoni Blood Fluke Schistosoma Mansoni Infection Snail Fever Acute Schistosomiasis Schistosomiasis Manson Schistosomiasis Due To Schistosoma Mansoni [Intestinal Schistosomiasis] Intestinal Schistosomiasis Nos Intestinal Schistosomiasis Egyptian Splenomegaly Bilharziasis Of Intestine Schistosomal Dysentery Schistosomiasis Of Colon Asiatic Schistosomiasis Eastern Schistosomiasis Schistosoma Japonicum Infection Schistosomiasis Japonicum Katayama Disease Katayama Syndrome Oriental Schistosomiasis
Mycobacterium Fortuitum
Lymphadenitis	Acute Lymphadenitis Chronic Lymphadenitis Adenitis Chronic Adenitis Acute Adenitis Inflammation Of Lymph Node Adenitis Nos Inflammation Of Gland Lymphatic Gland Inflammation Lymph Gland Inflammation Polyadenitis Chronic Adenitis Of Any Lymph Node Except Mesenteric Chronic Lymphadenitis Except Mesenteric Chronic Non-Specific Lymphadenitis
Leishmaniasis	Post-Kala-Azar Dermal Leishmaniasis Post Kala-Azar Dermal Leishmaniasis Post-Kala-Azar Dermal Infectious Disease By Leishmaniasis Cutaneous Leishmaniasis Kala-Azar Visceral Leishmaniasis Leishmaniasis, Cutaneous Leishmaniasis, Visceral Leishmania Leishmania Infection Leishmaniosis
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Omenn Syndrome	Histiocytic Medullary Reticulosis Severe Combined Immunodeficiency With Hypereosinophilia Combined Immunodeficiency With Hypereosinophilia Reticuloendotheliosis, Familial, With Eosinophilia Reticuloendotheliosis Familial With Eosinophilia Familial Reticuloendotheliosis Omenn'S Syndrome OS Malignant Histiocytosis
Immunodeficiency 28	IMD28 Ifngr2 Deficiency Immunodeficiency 28, Mycobacteriosis, Autosomal Recessive Immunodeficiency 28, Mycobacteriosis Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar2 Deficiency Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 2 Deficiency Msmd Due To Complete Ifngammar2 Deficiency Msmd Due To Complete Interferon Gamma Receptor 2 Deficiency Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar2 Deficiency Autosomal Recessive Msmd Due To Partial Ifngammar2 Deficiency Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 2 Deficiency Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 2 Deficiency Immunodeficiency, Type 28, Mycobacteriosis
Macs Syndrome	Macrocephaly, Alopecia, Cutis Laxa, And Scoliosis Mycobacterium Avium Complex Disease Rin2 Syndrome Mycobacterium Avium-Intracellulare Infection Tall Forehead, Sparse Hair, Skin Hyperextensibility, And Scoliosis Mycobacterium Avium Complex Mycobacterium Avium Infection Infection Due To Mycobacterium Intracellulare Mac Disease Macrocephaly-Alopecia-Cutis Laxa-Scoliosis Syndrome Rin2 Deficiency Tall Forehead-Sparse Hair-Skin Hyperextensibility-Scoliosis Syndrome MACS Macrocephaly Alopecia Cutis Laxa And Scoliosis Syndrome
Mycobacterium Tuberculosis 1	Tuberculosis Tuberculoma Tuberculosis, Susceptibility To Mycobacterium Tuberculosis, Susceptibility To, 1 Mtbs1 TB
Penicillin Allergy	Allergy To Penicillin
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Disease By Infectious Agent	Infectious Disease Infectious Diseases
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Axillary Adenitis	Axillary Lymphadenitis
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Miliary Tuberculosis	Acute Miliary Tuberculosis Disseminated Tuberculosis Tuberculosis, Miliary Generalized Tuberculosis Tuberculosis Miliaris Disseminata Tuberculosis Miliary Tuberculosis Disseminated Miliary Tb - [Tuberculosis] Generalised Tuberculosis Concato Disease Diffuse Necrotic Tuberculosis Diffuse Necrotizing Tuberculosis Diffuse Tuberculous Degeneration Diffuse Tuberculous Gangrene Mtb - [Miliary Tuberculosis] Miliary Tuberculous Miliary Tuberculosis Unspecified Disseminated Miliary Tuberculosis Disseminated Necrotic Tuberculosis Disseminated Necrotizing Tuberculosis Disseminated Tuberculous Gangrene Disseminated Tuberculous Degeneration
Eczema Herpeticum	Herpes Simplex Dermatitis Herpes Simplex Eyelid Dermatitis Kaposi Varicelliform Eruption Herpes Simplex Dermatitis Of Eyelid Herpes Simplex Virus Dermatitis Herpes Simplex Virus Eyelid Dermatitis
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Chronic Mucocutaneous Candidiasis	Candidiasis, Chronic Mucocutaneous Cmc Candidiasis Chronic Mucocutaneous

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS17474	Ifngr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P10840	Tkip	Inhibitor	95.16%	Unkown
HY-RS06588	IFNGR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23932	Ifngr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	IFNGR1	VGNC	VGNC:30058
Felis catus	IFNGR1	VGNC	VGNC:67704
Canis familiaris	IFNGR1	VGNC	VGNC:41880
Rattus norvegicus	IFNGR1	RGD	RGD:620570
Mus musculus	IFNGR1	MGD	MGI:107655
Macaca mulatta	IFNGR1	VGNC	VGNC:81080
Others	IFNGR1	NCBI