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PAQR8 - progestin and adipoQ receptor family member 8 Gene

Also Known as MPRB; LMPB1; C6orf33

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 85315

About PAQR8

Cytogenetic location: 6p12.2 Genomic coordinates (GRCh38): 6:52,362,151-52,407,777 (from NCBI)

This gene has 3 transcripts (splice variants), 225 orthologues and 10 paralogues. Broad expression in brain (RPKM 26.8), colon (RPKM 23.1) and 21 other tissues.

Summary

Predicted to enable steroid binding activity and steroid hormone receptor activity. Predicted to be involved in response to steroid hormone. Located in Golgi apparatus and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PAQR8 Products (1)

mRNA	Protein	Name
NM_133367.5	NP_588608.1	membrane progestin receptor beta

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAQR8 Protein Structure

HlyIII

0
100
200
300
354 a.a.

Protein Preferred Names	Protein Names
membrane progestin receptor beta	lysosomal membrane protein in brain-1

PAQR8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PAQR8	Q8TEZ7	LEPROTL1	Homo sapiens	O95214	Y2H Prey Pooling	32296183
Intra	PAQR8	Q8TEZ7	LEPROTL1	Homo sapiens	O95214	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Myositis Fibrosa	Interstitial Myositis
Epilepsy, Myoclonic Juvenile	Juvenile Myoclonic Epilepsy Janz Syndrome Jme Myoclonic Epilepsy, Juvenile, Susceptibility To, 1 EJM Myoclonic Epilepsy, Juvenile Petit Mal, Impulsive Myoclonic Epilepsy, Juvenile 1 Myoclonic Epilepsy, Juvenile, 1 Adolescent Myoclonic Epilepsy Juvenile Myoclonus Epilepsy Juvenile Myoclonic Epilepsy 1 EJM1 Petit Mal Impulsive Susceptibility To Juvenile Myoclonic Epilepsy 1 Myoclonic Epilepsy Juvenile Epilepsy, Myoclonic, Juvenile Myoclonic Epilepsy Of Janz Jme - [Juvenile Myoclonic Epilepsy]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS10035	PAQR8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PAQR8	VGNC	VGNC:32580
Macaca mulatta	PAQR8	VGNC	VGNC:75610
Canis familiaris	PAQR8	VGNC	VGNC:57227
Felis catus	PAQR8	VGNC	VGNC:102480
Mus musculus	PAQR8	MGD	MGI:1921479
Rattus norvegicus	PAQR8	RGD	RGD:1311710
Others	PAQR8	NCBI