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Cat. No.: HY-151116

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HER2-IN-10

HER2-IN-10 is a psoralen derivative. HER2-IN-10 has anti-breast cancer activity and light-activated cytotoxicity. HER2-IN-10 induces apoptosis.

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CAS No.: 1059177-03-5
화학식: C₁₅H₁₃NO₅
분자량:287.27

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

HER2-IN-10 Chemical Structure

CAS No.: 1059177-03-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

HER2-IN-10 is a psoralen derivative. HER2-IN-10 has anti-breast cancer activity and light-activated cytotoxicity. HER2-IN-10 induces apoptosis^[1].

In Vitro

HER2-IN-10 (50 µM) has phototoxicity against SK-BR-3 cells with the IC₅₀ of 3.05 µM^[1].
HER2-IN-10 (1-50 µM; 48 h) changes the morphology of the SK-BR-3 cells under UVA irradiation and increases the apoptotic index^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

SK-BR-3 cells
Concentration:

1, 2.5, 5, 10, 20 and 50 µM
Incubation Time:

48 hours
Result:

Broken down cells into apoptotic bodies at higher concentrations (10, 20, and 50 µM) and cell shrinkage, plasma membrane blebbing at lower concentrations (1, 2.5, and 5 µM).

Chemical Information

CAS No. 1059177-03-5
분자량 287.27
화학식 C₁₅H₁₃NO₅
SMILES

CCC(NC(C1=C(OC=C1)C(OC)=C2O3)=C2C=CC3=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Aekrungrueangkit C, et, al. Novel psoralen derivatives as anti-breast cancer agents and their light-activated cytotoxicity against HER2 positive breast cancer cells. Sci Rep. 2022 Aug 5;12(1):13487. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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