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Cat. No.: HY-153811R

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IAG933 (Standard)

Name: IAG933 (Standard)
Brand: MedChemExpress
SKU: HY-153811R
Availability: PreOrder

(Synonyms: YAP-TEAD-IN-3 (Standard))

IAG933 (Standard) is the analytical standard of IAG933 (HY-153811). This product is intended for research and analytical applications. IAG933 (YAP-TEAD-IN-3) is an orally available YAP/TAZ-TEAD inhibitor that has anti-tumor effects and promotes apoptosis. IAG933 YAP-TEAD-IN-3 inhibits Avi-human TEAD^4217-434, with an IC₅₀ value of 9 nM.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2714434-21-4
화학식: C₂₇H₂₆ClF₂N₃O₄
분자량:529.96

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

IAG933 (Standard) Chemical Structure

CAS No.: 2714434-21-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Product Information

Information

신청

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 2714434-21-4
분자량 529.96
화학식 C₂₇H₂₆ClF₂N₃O₄
SMILES

ClC(C(F)=CC1=C2C[C@](C3=CC=CC=C3)([C@@H]4CCCN4)O1)=[C@]2[C@@]5=C(C(NC)=O)C=NC(OCCO)=C5F
Synonyms

YAP-TEAD-IN-3 (Standard)
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Bordas V, et al. Preparation of biaryl derivatives as YAP/TAZ-TEAD protein-protein interaction inhibitors. World Intellectual Property Organization, WO2021186324 A1. 2021-09-23.

[2]. Emilie A Chapeau， et al. Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers. Nat Cancer. 2024 Jul;5(7):1102-1120. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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