KY1070
KY1070 is a fully human anti-BMP6 antibody with a Kd of 0.00014 μM against the human BMP6. It exhibits high specificity for BMP6, showing no cross-reactivity with other members of the BMP family, and effectively inhibits BMP6-induced BMP receptor heterodimerization and hepcidin expression. KY1070 modulates Ferroportin expression on erythroid progenitor cells and accelerates erythropoiesis. In rodent anemia models, KY1070 reduces the required dose of erythropoietin (EPO) when used in combination with EPO and enhances the responsiveness of mice with chronic kidney disease (CKD)-associated anemia to EPO treatment. KY1070 is applicable for research on anemia of chronic disease [1] [2].
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
Species Reactivity
Human
IC50 & Target
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hBMP6 0.00014 μM (Kd) |
In Vitro
KY1070 (starting at a final concentration of 600 nM) binds recombinant human BMP6, neutralizes BMP6 from multiple species, lacks cross-reactivity to other BMPs, and inhibits BMPR heterodimerization (Kd = 140 pM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
KY1070 (0.1-3 mg/kg) increases EPO sensitivity in male C57BL/6N mice with CKD[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Bmp6 wild-type mice; Bmp6-deficient mice[1]
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Dosage:3 mg/kg
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Administration:single injection
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Result:Significantly decreased hepatic Hamp mRNA and increased plasma iron levels in Bmp6-wt mice; showed no effect on hepatic Hamp mRNA or plasma iron levels in Bmp6^-/- mice
Gene ID
Accession
P22004
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
신청
ELISA, FACS, Functional assay
Chemical Information
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Petzer V, et al. A fully human anti-BMP6 antibody reduces the need for erythropoietin in rodent models of the anemia of chronic disease. Blood. 2020 Aug 27;136(9):1080-1090. [Content Brief]
[2]. Mansour GK, et al. Therapeutic targeting of the hepcidin-ferroportin axis and erythropoietic modulators: a narrative review. Front Med (Lausanne). 2025;12:1726337. Published 2025 Dec 9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KY1070 Related Classifications
HY-P991881 Related Classifications
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